Featured Research

from universities, journals, and other organizations

Tracking down the origin of leukemia relapse

Date:
April 4, 2011
Source:
Rockefeller University Press
Summary:
The cancer cells that reign during relapses of an aggressive human leukemia are different from those that dominated the original disease, according to a new article.

The cancer cells that reign during relapses of an aggressive human leukemia are different from those that dominated the original disease, according to a paper published online on April 4 in the Journal of Experimental Medicine.

Related Articles


By comparing the DNA of cancer cells taken at the time of diagnosis and relapse from patients with T cell acute lymphoblastic leukemia (T-ALL), Jean Soulier and co-workers found that the relapse cells arose from cells that were scarce at the time of diagnosis. The relapse cells had also picked up several new and dangerous mutations. Mimicking these mutations in cells isolated at diagnosis rendered them more cancerous after injection into immune-depleted mice.

Untouched cancer cells from diagnosis samples also caused leukemia when injected into mice. And once established, they bore a closer genetic resemblance to relapse cells than to their former selves, suggesting that the most aggressive cancer cells prevail in both mouse and man.

These findings suggest that tracking human leukemia development in immune-depleted mice might provide insight into the mechanisms underlying relapses of the human disease.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Clappier, E., et al. Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse. J. Exp. Med., April 4, 2011 DOI: 10.1084/jem.20110105

Cite This Page:

Rockefeller University Press. "Tracking down the origin of leukemia relapse." ScienceDaily. ScienceDaily, 4 April 2011. <www.sciencedaily.com/releases/2011/04/110404121935.htm>.
Rockefeller University Press. (2011, April 4). Tracking down the origin of leukemia relapse. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2011/04/110404121935.htm
Rockefeller University Press. "Tracking down the origin of leukemia relapse." ScienceDaily. www.sciencedaily.com/releases/2011/04/110404121935.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
What's Different About This Latest Ebola Vaccine

What's Different About This Latest Ebola Vaccine

Newsy (Mar. 26, 2015) — A whole virus Ebola vaccine has been shown to protect monkeys exposed to the virus. Here&apos;s what&apos;s different about this vaccine. Video provided by Newsy
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) — Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins