Featured Research

from universities, journals, and other organizations

Scientists identify KRAS rearrangements in metastatic prostate cancer

Date:
April 4, 2011
Source:
American Association for Cancer Research
Summary:
Scientists have uncovered a genetic characteristic of metastatic prostate cancer that defines a rare sub-type of this disease.

Scientists have uncovered a genetic characteristic of metastatic prostate cancer that defines a rare sub-type of this disease. These findings are published in Cancer Discovery, the newest journal of the American Association for Cancer Research, which will debut at the AACR 102nd Annual Meeting 2011, held April 2-6 in Orlando, Florida.

Arul M. Chinnaiyan, M.D., Ph.D., an investigator of the Howard Hughes Medical Institute and director of the Michigan Center for Translational Pathology, and colleagues identified an oncogenic gene fusion of KRAS, one of the most studied and well-known oncogenes in a metastatic prostate cancer cell line.

Like most metastatic disease, metastatic prostate cancer has a grim prognosis. As scientists learn more about the genetic characteristics of this disease, they may be able to work backward and accurately predict which early-stage prostate cancers will be more aggressive and thus require additional therapy and management.

"Right now, we can identify the presence of prostate cancer but not accurately predict which of these cancers will have a poor prognosis," said Chinnaiyan. "Although prostate cancer is a leading cause of cancer-related death, we need better prognostic information to separate the slow growing tumors from the more aggressive ones."

Chinnaiyan compared the identification of the KRAS gene in metastatic prostate cancer to the work that has been previously done in breast cancer, where scientists now recognize that breast cancer comes in multiple subtypes and requires different treatment strategies.

"The more we know about the disease biologically, the better we'll be able to treat it," said Chinnaiyan.

Currently, there are no treatments that block the KRAS oncogene, but several are under development that target components of the KRAS signaling pathway.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Journal Reference:

  1. Xiao-Song Wang, Sunita Shankar, Saravana M. Dhanasekaran, Bushra Ateeq, Atsuo T. Sasaki, Xiaojun Jing, Daniel Robinson, Qi Cao, John R. Prensner, Anastasia K. Yocum, Rui Wang, Daniel F. Fries, Bo Han, Irfan A. Asangani, Xuhong Cao, Yong Li, Gilbert S. Omenn, Dorothee Pflueger, Anuradha Gopalan, Victor E. Reuter, Emily Rose Kahoud, Lewis C. Cantley, Mark A. Rubin, Nallasivam Palanisamy, Sooryanarayana Varambally, and Arul M. Chinnaiyan. Characterization of KRAS Rearrangements in Metastatic Prostate Cancer. Cancer Discovery, April 3, 2011 DOI: 10.1158/2159-8274.CD-10-0022

Cite This Page:

American Association for Cancer Research. "Scientists identify KRAS rearrangements in metastatic prostate cancer." ScienceDaily. ScienceDaily, 4 April 2011. <www.sciencedaily.com/releases/2011/04/110404122158.htm>.
American Association for Cancer Research. (2011, April 4). Scientists identify KRAS rearrangements in metastatic prostate cancer. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2011/04/110404122158.htm
American Association for Cancer Research. "Scientists identify KRAS rearrangements in metastatic prostate cancer." ScienceDaily. www.sciencedaily.com/releases/2011/04/110404122158.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins