Featured Research

from universities, journals, and other organizations

New compounds show promise against hepatitis C infection

Date:
April 13, 2011
Source:
Federation of American Societies for Experimental Biology
Summary:
Two bioflavonoids, catechin and naringenin, have displayed antiviral activity on tissue culture infected with Hepatitis C.

Approximately 270-300 million people worldwide are infected with hepatitis C, and about 1%-2% of the U.S. population is infected. This infectious disease can lead to scarring of the liver, cirrhosis, and eventually liver failure. A significant number of infected patients develop liver disease or cancer. The current standard treatment is interferon, which has only a 50% success rate. Compounding the 50% failure rate are severe side effects which lead many people to discontinue treatment.

Related Articles


Dr. Samuel Wheeler French Jr., MD, PhD, Assistant Professor of Pathology and Laboratory Medicine at UCLA and researcher at UCLA's Jonsson Comprehensive Cancer Center, is a liver pathologist who is currently developing a proteomic-based program to study the development of liver cancer from hepatitis C viral infection. His most recent study results, to be presented in an American Society for Investigative Pathology (ASIP) symposium on "Pathobiology of Liver Injury and Fibrosis" on April 12 at Experimental Biology 2011, evaluate the effects of several flavonoids on hepatitis C viral infection.

Previously, Dr. French has shown that quercetin, a plant-derived bioflavonoid used by some as a nutritional supplement, attenuates Hepatitis C virus production with no cell toxicity. In his most recent research, French and colleagues found that two other bioflavonoids, catechin and naringenin, displayed antiviral activity on tissue culture. The next step is to determine through a Phase I Clinical Trial that they are safe for patients with chronic hepatitis C infection.

"We now have several new compounds we can test to see if they reduce virus infection," said Dr. French. "The positive thing about this family of compounds is that they are nontoxic, and can be taken at high doses. Bioflavonoids represent a very promising therapy with very few side effects that could help millions of people."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Cite This Page:

Federation of American Societies for Experimental Biology. "New compounds show promise against hepatitis C infection." ScienceDaily. ScienceDaily, 13 April 2011. <www.sciencedaily.com/releases/2011/04/110412201709.htm>.
Federation of American Societies for Experimental Biology. (2011, April 13). New compounds show promise against hepatitis C infection. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2011/04/110412201709.htm
Federation of American Societies for Experimental Biology. "New compounds show promise against hepatitis C infection." ScienceDaily. www.sciencedaily.com/releases/2011/04/110412201709.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins