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Nanoscience may hold key to surgical recovery

Date:
April 26, 2011
Source:
University of York
Summary:
New nano-systems developed in the UK may eventually help patients recover from surgery without the danger of allergic reactions to drugs.
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New nano-systems developed in York may eventually help patients recover from surgery without the danger of allergic reactions to drugs.

Researchers from the University of York's Department of Chemistry have developed synthetic molecules capable of binding the chemical drug heparin, which they believe may provide an alternative to protamine.

During surgery patients are given heparin to thin the blood and prevent clotting. However, once surgery is finished, it is essential to remove the heparin and allow clotting so the patient can recover. Currently this is done with the drug protamine, a natural product extracted from shellfish which can cause serious side effects in some patients.

The synthetic molecules created in York are designed to self-assemble into nanometre-sized structures with similar dimensions to protamine and containing multiple heparin binding units.

The results of the early stage study, published in Angewandte Chemie, show that the new nano-systems are capable of binding heparin just as effectively as protamine.

Professor Dave Smith, from the Department of Chemistry, said: "Clearly there is lots of fundamental work still to be done before clinical application. However, we hope that this approach may eventually yield biocompatible and degradable heparin binders which will help surgical recovery without any of the side effects which can be caused by protamine."


Story Source:

The above post is reprinted from materials provided by University of York. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ana C. Rodrigo, Anna Barnard, James Cooper, David K. Smith. Self-Assembling Ligands for Multivalent Nanoscale Heparin Binding. Angewandte Chemie International Edition, 2011; DOI: 10.1002/anie.201100019

Cite This Page:

University of York. "Nanoscience may hold key to surgical recovery." ScienceDaily. ScienceDaily, 26 April 2011. <www.sciencedaily.com/releases/2011/04/110426081951.htm>.
University of York. (2011, April 26). Nanoscience may hold key to surgical recovery. ScienceDaily. Retrieved September 4, 2015 from www.sciencedaily.com/releases/2011/04/110426081951.htm
University of York. "Nanoscience may hold key to surgical recovery." ScienceDaily. www.sciencedaily.com/releases/2011/04/110426081951.htm (accessed September 4, 2015).

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