Featured Research

from universities, journals, and other organizations

Severity of hepatitis C and HIV co-infection in mothers contribute to HCV transmission to child

Date:
April 28, 2011
Source:
Wiley-Blackwell
Summary:
New research shows that high maternal viral load and co-infection with human immunodeficiency virus (HIV) are the only risk factors associated with vertical transmission of the hepatitis C virus (HCV-VT). A variation in the infant's IL28B gene is associated independently with the spontaneous clearance of HCV genotype-1 among infected children.

New research shows that high maternal viral load and co-infection with human immunodeficiency virus (HIV) are the only risk factors associated with vertical transmission of the hepatitis C virus (HCV-VT). A variation in the infant's IL28B gene (CC) is associated independently with the spontaneous clearance of HCV genotype-1 among infected children. The status of IL28B in the mother or children did not increase risk of HCV-VT in this study. Findings are published in the May issue of Hepatology, a peer-reviewed journal of the American Association for the Study of Liver Diseases.

Related Articles


Chronic HCV affects 170 million individuals worldwide, with 10% to 15% of cases leading to cirrhosis and liver cancer. A major route of infection in children is vertical transmission of HCV (HCV-VT) -- known also as mother-to-child transmission -- and may occur in utero or following birth (breast feeding). While medical evidence has described risk factors involved in HCV-VT, underlying transmission mechanisms and timing of disease transmission is not fully understood. Prior studies have investigated the relationship between HCV-VT and maternal HCV genotype, birth mode (vaginal or caesarean) and type of feeding (breast feeding or replacement), but results have been conflicting.

"Our study analyzed the role of IL28B in HCV-VT and the spontaneous clearance of HCV among infected infants," said Ángeles Ruiz Extremera, M.D., of San Cecilio University Hospital in Spain. The team recruited 145 mothers who were infected with HCV and gave birth between 1991 and 2009. All women were Caucasian -- 112 were HCV RNA positive and HIV negative; 33 were HCV RNA negative and HCV antibody positive. A total of 142 children were birthed by HCV-RNA positive mothers and 43 children to HCV-RNA negative mothers, all of whom were followed for six years or more. HCV-VT was defined as children who presented with HCV-RNA positive results from two blood samples.

Analysis showed that 61% of the 31 mothers with CC polymorphism, and 82% of the 68 mothers with non-CC polymorphism were HCV-RNA positive. There were 128 infants born to HCV-RNA positive mothers who were not co-infected with HIV and 20% of the children acquired HCV infection, with 7% of these being chronic cases. In mothers who were coinfected with HCV and HIV, the HCV-VT rate climbed to 43%. Researchers also noted that the rate of HCV-VT was higher among mothers who had elevated HCV viremia levels. Researchers did not detect HCV-VT in HCV-RNA negative mothers.

An increased risk of HCV-VT was not associated with the mothers' or children's IL28B status. However, researchers found that genotype non-1 and CC of the IL28B gene were involved with viral clearance among children infected with HCV. In regression analysis the child CC polymorphism was the only predictor of spontaneous HCV clearance in HCV genotype-1. "Our data are the first to account for HCV virus clearance and may provide important information about protective immunity to HCV," concluded Dr. Ruiz Extremera. "Further investigation is needed to understand the mechanisms involved with this genetic variation and the clinical impact of the IL28B variant on HCV infection."


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ángeles Ruiz-Extremera, JoséAntonio Muñoz-Gámez, María Angustias Salmerón-Ruiz, Paloma Muñoz de Rueda, Rosa Quiles-Pérez, Ana Gila-Medina, Jorge Casado, Ana Belén Martín, Laura Sanjuan-Nuñez, Ángel Carazo, Esther José Pavón, Esther Ocete-Hita, Josefa León, Javier Salmerón. Genetic variation in IL28B with respect to vertical transmission of hepatitis C virus and spontaneous clearance in HCV infected children. Hepatology, 2011; DOI: 10.1002/hep.24298

Cite This Page:

Wiley-Blackwell. "Severity of hepatitis C and HIV co-infection in mothers contribute to HCV transmission to child." ScienceDaily. ScienceDaily, 28 April 2011. <www.sciencedaily.com/releases/2011/04/110427131826.htm>.
Wiley-Blackwell. (2011, April 28). Severity of hepatitis C and HIV co-infection in mothers contribute to HCV transmission to child. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2011/04/110427131826.htm
Wiley-Blackwell. "Severity of hepatitis C and HIV co-infection in mothers contribute to HCV transmission to child." ScienceDaily. www.sciencedaily.com/releases/2011/04/110427131826.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) — An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins