Featured Research

from universities, journals, and other organizations

Novel noninvasive tests for early cancer detection

Date:
May 3, 2011
Source:
Mary Ann Liebert, Inc./Genetic Engineering News
Summary:
Researchers are intensifying efforts to identify and validate various types of biomarkers that are detectable in readily accessible bodily fluids such as blood and urine.

Researchers at last month's AACR conference in Orlando demonstrated that they are intensifying their efforts to identify and validate various types of biomarkers that are detectable in readily accessible bodily fluids such as blood and urine, reports Genetic Engineering & Biotechnology News (GEN). The goal is to detect biosignatures that are more specific and sensitive than existing diagnostic modalities, according to the May 1 issue of GEN .

"The molecular diagnostic approach is geared toward finding tumors earlier in the course of disease," says John Sterling, Editor in Chief of GEN. "This could reduce the need for more invasive and costly biopsies and imaging studies and lead to earlier therapeutic intervention."

At the AACR meeting, Harvey Pass, M.D., New York University Langone Medical Center and Cancer Center, discussed his group's experience working in collaboration with SomaLogic to develop an aptamer-based diagnostic to detect malignant mesothelioma in asbestos-exposed individuals. Dr. Pass presented data derived from the application of biomarker subsets to a blinded test set, demonstrating 100% specificity and 80% sensitivity for their ability to distinguish asbestos-exposed controls from mesothelioma cases.

Another presentation pointed out that measurement of CA125 in the blood is the test currently used to monitor ovarian cancer treatment, follow patients for recurrence, and in some cases screen high-risk individuals to detect early-stage disease. In her conference talk, Christine Coticchia, Ph.D., Children's Hospital Boston and Harvard Medical School, emphasized that CA125 is relatively nonspecific for ovarian cancer and uninformative in a substantial percentage of patients. Dr. Coticchia and colleagues are studying a combination of two matrix metalloproteases, MMP-2 and MMP-9, in urine for their utility as biomarkers to predict the presence of ovarian cancer in women with normal CA125 levels.

Other research projects covered in the GEN article include work at Celera, the Fred Hutchinson Cancer Research Center, University of Michigan Health System, Gen-Probe, University of California at San Diego Medical Center, Universitι Laval, Dianon Systems, Aarhus University Hospital, Hvidovre Hospital, University of Copenhagen, and Exiqon.


Story Source:

The above story is based on materials provided by Mary Ann Liebert, Inc./Genetic Engineering News. Note: Materials may be edited for content and length.


Journal Reference:

  1. Vicki Glaser. Cancer Detection Improved with Noninvasive Testing. Genetic Engineering & Biotechnology News, May 1, 2011 (Vol. 31, No. 9) [link]

Cite This Page:

Mary Ann Liebert, Inc./Genetic Engineering News. "Novel noninvasive tests for early cancer detection." ScienceDaily. ScienceDaily, 3 May 2011. <www.sciencedaily.com/releases/2011/05/110503151602.htm>.
Mary Ann Liebert, Inc./Genetic Engineering News. (2011, May 3). Novel noninvasive tests for early cancer detection. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2011/05/110503151602.htm
Mary Ann Liebert, Inc./Genetic Engineering News. "Novel noninvasive tests for early cancer detection." ScienceDaily. www.sciencedaily.com/releases/2011/05/110503151602.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) — The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) — Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) — Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:  

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile iPhone Android Web
      Follow Facebook Twitter Google+
      Subscribe RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins