Featured Research

from universities, journals, and other organizations

Mouse study turns fat-loss/longevity link on its head

Date:
May 4, 2011
Source:
University of Texas Health Science Center at San Antonio
Summary:
Food restriction in 41 different strains of mice showed that, contrary to a widely held view, the animals' loss of fat did not necessarily result in longer life.

Since the 1930s scientists have proposed food restriction as a way to extend life in mice. Though feeding a reduced-calorie diet has indeed lengthened the life spans of mice, rats and many other species, new studies with dozens of different mouse strains indicate that food restriction does not work in all cases.

Diet and fat loss

Researchers at the UT Health Science Center San Antonio's Barshop Institute for Longevity and Aging Studies, with colleagues at the University of Colorado, studied the effect of food restriction on fat and weight loss in 41 genetically different strains of mice. The scientists then correlated the amount of fat reduction to life span.

The answer: Mice that maintained their fat actually lived longer. Those that lost fat died earlier.

Contrary to view

"Indeed, the greater the fat loss, the greater the likelihood the mice would have a negative response to dietary restriction, i.e., shortened life," said James Nelson, Ph.D., professor of physiology at the Barshop Institute. "This is contrary to the widely held view that loss of fat is important for the life-extending effect of dietary restriction. It turns the tables a bit."

The results are expected to be published in the June issue of Aging Cell.

More study needed

Dr. Nelson's graduate student, Chen-Yu Liao, who will soon receive his Ph.D. and advance to a postdoctoral fellowship at California's Buck Institute for Research on Aging, cautioned that the new findings cannot be directly applied to people until similar studies are done in humans.

People are best advised to adopt a moderate approach, not losing all fat but definitely not keeping unhealthy amounts of fat, either.

"None of the mice in this study were what we would consider to be obese," Liao said.

Genes impact effect

The findings bear out what geneticists long have said: there is nothing that works for every genotype, which is an organism's specific and unique set of genes.

"We know that humans respond to diet very differently as individuals based on their genetics," Dr. Nelson said. "Some have great difficulty losing weight while others have difficulty maintaining weight. If these results translate to humans, they would suggest that individuals who have difficulty losing weight may benefit from the positive effects of dietary restriction more than those who lose weight easily."


Story Source:

The above story is based on materials provided by University of Texas Health Science Center at San Antonio. Note: Materials may be edited for content and length.


Journal Reference:

  1. Chen-Yu Liao, Brad A. Rikke, Thomas E. Johnson, Jonathan A.L. Gelfond, Vivian Diaz, James F. Nelson. Fat Maintenance Is a Predictor of the Murine Lifespan Response to Dietary Restriction. Aging Cell, 2011; DOI: 10.1111/j.1474-9726.2011.00702.x

Cite This Page:

University of Texas Health Science Center at San Antonio. "Mouse study turns fat-loss/longevity link on its head." ScienceDaily. ScienceDaily, 4 May 2011. <www.sciencedaily.com/releases/2011/05/110503161409.htm>.
University of Texas Health Science Center at San Antonio. (2011, May 4). Mouse study turns fat-loss/longevity link on its head. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2011/05/110503161409.htm
University of Texas Health Science Center at San Antonio. "Mouse study turns fat-loss/longevity link on its head." ScienceDaily. www.sciencedaily.com/releases/2011/05/110503161409.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins