Featured Research

from universities, journals, and other organizations

Childhood cancer survivors are at increased risk for ongoing post-therapy GI complications

Date:
May 4, 2011
Source:
American Gastroenterological Association
Summary:
Patients who received therapy for cancer during childhood have an increased risk of developing gastrointestinal complications later in life.

Patients who received therapy for cancer during childhood have an increased risk of developing gastrointestinal (GI) complications later in life, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute. Compared with their siblings, cancer survivors had an increased risk of late-onset complications of the upper GI tract, lower GI tract and liver.

"Survivors are at elevated risk for ongoing gastrointestinal complications after therapy," said Robert Goldsby, MD, of the University of California, San Francisco Children's Hospital and lead author of the study. "Because these gastrointestinal complications may impact quality of life, health-care providers should be aware of potential gastrointestinal problems in this population as they evaluate acute symptoms and plan ongoing follow-up care."

As more children diagnosed with cancer are surviving long-term, it is increasingly important to recognize the long-term consequences of their cancer and its therapy. This analysis shows that survivors of childhood cancer have a higher incidence of self-reported GI complaints compared with their siblings. Risks for colostomy/ileostomy, cirrhosis or liver biopsy were highest. Older age at diagnosis, exposure to abdominal radiation and certain chemotherapy treatments increase that risk. More than 40 percent of childhood cancer survivors reported a late GI complication by 20 years after cancer therapy. The probability of experiencing a late GI consequence was greater in survivors compared to siblings. The survivor's prior experience may increase their sensitivity to GI-related symptoms, but cancer treatments may cause direct damage to the GI organ system.

"The risks of late GI complications may change as therapy for childhood and adolescent cancer continues to evolve and will require studies of more recently treated patients," added Dr. Goldsby. Although various disease-specific combinations of chemotherapy, radiation and surgery have dramatically improved survival, these treatment modalities have the potential to cause significant GI complications. For example, abdominal radiation often results in several acute toxicities, including intestinal inflammation and abnormal movement of the intestinal tract. Chemotherapy is associated with many acute GI toxicities, including nausea, vomiting, diarrhea, constipation and increased susceptibility to GI infections. Intra-abdominal surgery and subsequent GI complications are also contributors to GI toxicity of cancer therapy. Long-term GI consequences, however, have not been extensively studied.

In this study, doctors evaluated the incidence of long-term GI outcomes and identified treatment-related risk factors. The goals of this analysis were to describe the incidence of self-reported adverse GI conditions occurring at least five years after diagnosis and to evaluate the effect of different treatment-associated factors on the risk of developing these GI events.

Upper GI, lower GI and liver adverse outcomes were assessed in cases from participants in the Childhood Cancer Survivor Study, a study of 14,358 survivors of childhood cancer (i.e., leukemias, brain tumors, lymphomas, Wilms tumor, neuroblastoma, sarcomas and bone tumors) who were diagnosed between 1970 and 1986 at one of 26 collaborating institutions in the U.S. and Canada; data were compared with those from randomly selected siblings. The median age at cancer diagnosis was 6.8 years, and the median age at outcome assessment was 23.2 years for survivors and 26.6 years for siblings.


Story Source:

The above story is based on materials provided by American Gastroenterological Association. Note: Materials may be edited for content and length.


Journal Reference:

  1. Robert Goldsby, Yan Chen, Shannon Raber, Linda Li, Karen Diefenbach, Margarett Shnorhavorian, Nina Kadan–Lottick, Fay Kastrinos, Yutaka Yasui, Marilyn Stovall, Kevin Oeffinger, Charles Sklar, Gregory T. Armstrong, Leslie L. Robison, Lisa Diller. Survivors of Childhood Cancer Have Increased Risk of Gastrointestinal Complications Later in Life. Gastroenterology, 2011; DOI: 10.1053/j.gastro.2011.01.049

Cite This Page:

American Gastroenterological Association. "Childhood cancer survivors are at increased risk for ongoing post-therapy GI complications." ScienceDaily. ScienceDaily, 4 May 2011. <www.sciencedaily.com/releases/2011/05/110504151339.htm>.
American Gastroenterological Association. (2011, May 4). Childhood cancer survivors are at increased risk for ongoing post-therapy GI complications. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2011/05/110504151339.htm
American Gastroenterological Association. "Childhood cancer survivors are at increased risk for ongoing post-therapy GI complications." ScienceDaily. www.sciencedaily.com/releases/2011/05/110504151339.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins