Featured Research

from universities, journals, and other organizations

Blood test for lung cancer? Characteristic patterns in microRNA reveal disease

Date:
May 12, 2011
Source:
Ohio State University Medical Center
Summary:
Researchers have identified characteristic patterns of molecules called microRNA in the blood of people with lung cancer that might reveal both the presence and aggressiveness of the disease, and perhaps who is at risk of developing it. These patterns may be detectable up to two years before the tumor is found by computed tomography (CT) scans. The findings could lead to a blood test for lung cancer.

Researchers have identified characteristic patterns of molecules called microRNA (miRNA) in the blood of people with lung cancer that might reveal both the presence and aggressiveness of the disease, and perhaps who is at risk of developing it. These patterns may be detectable up to two years before the tumor is found by computed tomography (CT) scans.

The findings could lead to a blood test for lung cancer, according to a researcher with the Ohio State University Comprehensive Cancer Center -- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute who helped lead study.

"We found patterns of abnormal microRNAs in the plasma of people with lung cancer and showed that it might be possible to use these patterns to detect lung cancer in a blood sample," says principal investigator Dr. Carlo M. Croce, professor of molecular virology, immunology and medical genetics, and director of the Human Cancer Genetics program.

"These abnormal microRNAs were present in blood serum well before the tumors were detected by a sensitive method such as spiral CT scan, suggesting they might have strong predictive, diagnostic and prognostic potential."

The findings were published in a recent issue of the Proceedings of the National Academy of Sciences.

Croce and his collaborators initially identified the molecular patterns in tissue samples collected from patients participating in a clinical trial examining the use of spiral CT scans to screen for lung cancer. The trial involved 1,035 individuals aged 50 years or older who had smoked at least a pack of cigarettes a day for 20 years or more. All patients underwent a CT scan every year for five years and provided blood, sputum and urine samples.

The researchers initially analyzed 28 tumor samples and 24 samples of normal-lung tissue for their miRNA profiles. They identified miRNAs that could discriminate between lung tumor and normal lung tissue. They also found patterns of miRNAs that distinguished tumors with faster growth rates and that correlated with poor disease-free survival.

Then Croce and his colleagues analyzed blood samples that had been collected more than a year before the individual's lung cancer was detected by spiral CT. They discovered a signature of 15 miRNAs that could identify 18 of 20 individuals whose cancer was later detected by spiral CT.

To verify that finding, they applied the signature to a second set of blood samples collected during a similar but unrelated lung-cancer trial. Here, the signature correctly identified 12 of 15 patients whose lung tumors were detected more than a year later by spiral CT. The researchers estimated that the signature were detectable in blood up to 28 months prior to spiral CT detection.

The researchers also found miRNA signatures in the blood that were associated with the following:

  • Lung-cancer diagnosis -- a signature identified 16 of 19 patients with lung cancer in set one, and 12 of 16 patients in set two.
  • Poor prognosis -- a signature identified five of five patients with poor prognosis in set one; four of five in set two.
  • Good prognosis -- a signature identified five of 15 patients in set one, and five of 11 patients in set two.

"Our goal was to identify biomarkers that could predict tumor development and prognosis to improve lung-cancer diagnosis and treatment," Croce says. "Overall, these findings strengthen the observation that circulating miRNA in plasma is detectable well before clinical disease detection by spiral CT, indicating the possibility of identifying high-risk patients on the basis of miRNA profiling."


Story Source:

The above story is based on materials provided by Ohio State University Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. Boeri, C. Verri, D. Conte, L. Roz, P. Modena, F. Facchinetti, E. Calabro, C. M. Croce, U. Pastorino, G. Sozzi. MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer. Proceedings of the National Academy of Sciences, 2011; 108 (9): 3713 DOI: 10.1073/pnas.1100048108

Cite This Page:

Ohio State University Medical Center. "Blood test for lung cancer? Characteristic patterns in microRNA reveal disease." ScienceDaily. ScienceDaily, 12 May 2011. <www.sciencedaily.com/releases/2011/05/110512171529.htm>.
Ohio State University Medical Center. (2011, May 12). Blood test for lung cancer? Characteristic patterns in microRNA reveal disease. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2011/05/110512171529.htm
Ohio State University Medical Center. "Blood test for lung cancer? Characteristic patterns in microRNA reveal disease." ScienceDaily. www.sciencedaily.com/releases/2011/05/110512171529.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins