Featured Research

from universities, journals, and other organizations

Stem cells from bone marrow may help treat acute lung injury

Date:
May 13, 2011
Source:
BioMed Central
Summary:
New research investigates the therapeutic use of human stem cells from bone marrow against acute lung injury and identifies TNF-alpha-induced protein 6 as a major molecular component of stem cell action.

New research, published in BioMed Central's open access journal Stem Cell Research & Therapy, investigates the therapeutic use of human stem cells from bone marrow against acute lung injury and identifies TNF-α-induced protein 6 as a major molecular component of stem cell action.

Acute lung injury is a major complication of critically ill patients resulting in pulmonary edema, hypoxia and, in the worst cases, organ failure. Consequently up to 40% of all sufferers die because their bodies' immune systems overreact in an attempt to repair the original lung damage.

Researchers based in Louisiana showed that therapy with human multipotent stromal cells (hMSC) isolated from bone marrow was able to significantly reduce acute lung injury in mice after 48 hours. At 24 hours the therapy could be seen to be working, reducing the amount of pulmonary edema and protein in the lungs. While injury increased the number of white blood cells (neutrophils) ten fold, this could be reduced by treatment with hMSC.

When the researchers looked in more detail, they found that hMSC treatment reduced over half of the inflammatory proteins tested, including IL-1α, Il-1β, IL-6 and RANTES. hMSC treatment also increased the amount of the anti-inflammatory proteins TNF-α-induced protein 6 (TSG6) and Interleukin 1 receptor antagonist (IL-1RN).

Dr Sullivan, from the Center for Stem Cell Research and Regenerative Medicine at Tulane University School of Medicine, said, "Our research reveals an important mechanism behind the anti-inflammatory activity of stem cells in lung injury because blocking the activity of TSG6 using siRNA prevented most of the anti-inflammatory effects of hMSC.

"Stem cell therapy shows great promise in the treatment of acute and life threatening conditions, such as acute lung injury and acute respiratory distress syndrome. Understanding the mechanisms by which hMSC dampen inflammation will likely provide strategies to improve the therapeutic potential of hMSCs for treatment of lung injury. Since it is a simple procedure to collect stem cells from bone marrow, we hope that our research paves the way forward into clinical trials."


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Svitlana Danchuk, Joni H Ylostalo, Fokhrul Hossain, Randy Sorge, Austin Ramsey, Ryan W Bonvillain, Joseph A Lasky, Bruce A Bunnell, David A Welsh, Darwin J Prockop and Deborah E Sullivan. The Human multipotent stromal cells attenuate lipopolysaccharide-induced acute lung injury in mice via secretion of tumor necrosis factor--induced protein 6. Stem Cell Research & Therapy, 2011; (in press)

Cite This Page:

BioMed Central. "Stem cells from bone marrow may help treat acute lung injury." ScienceDaily. ScienceDaily, 13 May 2011. <www.sciencedaily.com/releases/2011/05/110512214458.htm>.
BioMed Central. (2011, May 13). Stem cells from bone marrow may help treat acute lung injury. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2011/05/110512214458.htm
BioMed Central. "Stem cells from bone marrow may help treat acute lung injury." ScienceDaily. www.sciencedaily.com/releases/2011/05/110512214458.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins