Featured Research

from universities, journals, and other organizations

Detecting lung cancer early: Researchers lay foundation for future blood test

Date:
May 31, 2011
Source:
Universität Bonn
Summary:
A person's blood reveals whether he or she has lung cancer, according to researchers in Germany. The scientists are developing a blood test for smokers which could save human lives in the future, since the earlier a lung tumor is detected, the better the chances of survival are.

A person's blood reveals whether he or she has lung cancer, according to researchers at the University of Bonn in Germany. In collaboration with colleagues at the Cologne University Hospital, they are developing a blood test for smokers which could save human lives in the future, since the earlier a lung tumor is detected, the better the chances of survival are.

Related Articles


The study has just been published in the journal Clinical Cancer Research.

Scientists working with Professor Dr. Joachim L. Schultze have identified over 480 molecules whose concentration in the blood changes when a person develops lung cancer. These molecules are present in the blood cells either in increased or decreased quantities. "In lung cancer patients, typical patterns which can be detected with a measuring program thus emerge," explains Prof. Schultze. The molecules are nucleic acids which form in the body when certain genes are transcribed.

The changes in the blood also occur if the tumor is still in a very early stage. In lung cancer, there are four different stages, explains Prof. Schultze: "The prognosis for patients in stage 3 and 4 is still very poor even today; even with the most modern therapies, the point of death can only be postponed." Lung cancer in stage 1, on the other hand, can be treated surgically and it can even be cured in many cases. "Today, however, a tumor is seldom detected so early, namely in only about 15% of all cases. If a simple screening blood test would increase this percentage, a large proportion of lung cancer patients could survive," says Prof. Schultze. By contrast, to date, over 80% of all lung cancer patients die within two years after diagnosis, since the tumor is already too far advanced.

Screening for lung cancer: Results within a day

In the future, a lung cancer screening test may become part of routine practice: The doctor takes a blood sample from his/her patient, and within 24 hours, he knows with a high degree of certainty whether the patient has lung cancer or not − even if the patient does not yet have any symptoms.

For many years, the team working with Prof. Joachim Schultze has investigated the blood of over 200 smokers. About half of them had lung cancer; the others were either entirely healthy or suffered from another lung disease. "It was important to us that a subsequent test not only be able to differentiate lung cancer patients from healthy subjects, but also from persons with chronic lung diseases." The researchers then examined the research subjects' blood using biochips for certain nucleic acids and in doing so, they found the typical patterns.

The researchers are presently planning an analogous but much larger study with ten times as many patients, in order to confirm the results. If the present results prove to be true in such a study, there would no longer be anything standing in the way of developing the blood test to the point of being ready to be put on the market.


Story Source:

The above story is based on materials provided by Universität Bonn. Note: Materials may be edited for content and length.


Journal Reference:

  1. T. Zander, A. Hofmann, A. Staratschek-Jox, S. Classen, S. Debey-Pascher, D. Eggle, S. Ansén, M. Hahn, M. Beyer, R.K. Thomas, B. Gathof, C. Mauch, K.-S. Delank, W. Engel-Riedel, H.-E. Wichmann, E. Stoelben, J.L. Schultze, J. Wolf. Blood-based gene expression signatures in non-small cell lung cancer. Clinical Cancer Research, 2011

Cite This Page:

Universität Bonn. "Detecting lung cancer early: Researchers lay foundation for future blood test." ScienceDaily. ScienceDaily, 31 May 2011. <www.sciencedaily.com/releases/2011/05/110516080116.htm>.
Universität Bonn. (2011, May 31). Detecting lung cancer early: Researchers lay foundation for future blood test. ScienceDaily. Retrieved November 22, 2014 from www.sciencedaily.com/releases/2011/05/110516080116.htm
Universität Bonn. "Detecting lung cancer early: Researchers lay foundation for future blood test." ScienceDaily. www.sciencedaily.com/releases/2011/05/110516080116.htm (accessed November 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, November 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) — Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) — Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) — Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com
Ebola: Life Without School in Guinea

Ebola: Life Without School in Guinea

AFP (Nov. 21, 2014) — Following the closure of schools and universities in Guinea because of the Ebola virus, students look for temporary work or gather in makeshift classrooms to catch up on their syllabus. Duration: 02:14 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins