Featured Research

from universities, journals, and other organizations

Winding back the clock with kidney stem cells

Date:
May 18, 2011
Source:
Monash University
Summary:
Scientists in Australia have shown that they can make human stem cells from healthy adult kidneys without working on human embryos, circumventing ethical concerns around this research.

Stem cell research courts both controversy and support in the community- depending on your viewpoint.

Related Articles


Now, for the first time, scientists at Monash University's Immunology and Stem Cell Laboratories (MISCL) have shown that they can make human stem cells from healthy adult kidneys without working on human embryos, circumventing ethical concerns around this research.

This achievement will allow group leader Associate Professor Sharon Ricardo and her team to model genetic kidney diseases in the laboratory and tease out the mechanisms that control these difficult-to-treat disorders.

"We're taking human kidney cells and winding back the clock to make their early precursors," Ricardo said.

For the challenging project, which was published in the Journal of the American Society of Nephrology, the Monash researchers started with healthy adult kidney cells, which they reprogrammed back to an embryonic-like state, then compared these kidney stem cells with off-the-shelf embryonic stem cells, and showed that both could form different embryonic tissue types, with their genetic features preserved.

"These kidney cells had their slate wiped clean. Now that gives us the opportunity to change that kidney precursor into all kidney cell types," Ricardo said.

In collaboration with Professor Peter Kerr from Monash Medical Centre, the research team has now generated four stem cell lines from patients with polycystic kidney disease and Alport syndrome, two leading genetic kidney disorders.

"As these stem cells can divide indefinitely in a culture dish, we can make a limitless source of patient-specific stem cells, make kidney cysts and screen drugs on those cells," Ricardo said.

"Our ultimate goal is to make off-the-shelf mature kidney cells that patients can use for drug testing and disease modelling."

Ricardo, who is approaching pharmaceutical companies to screen drugs on the kidney stem cells, believes that this personalised medicine approach will produce safer medicines in the future.

But in the short-term, the Monash researcher plans to continue work on the kidney stem cells to study how environmental factors influence how kidney cells behave, tests drugs for their ability to reduce kidney cyst formation and cell proliferation, and better understand how genetic kidney disorders develop in the first place.

Ricardo, who was funded by the Australian Stem Cell Centre and Alport Foundation, Australia, collaborated with six Monash researchers including lead author Bi Song and Professor Claude Bernard; Professor Peter Kerr, Monash Medical Centre; and Dr Andrew Laslett from CSIRO Molecular and Health Technologies, also in Clayton.


Story Source:

The above story is based on materials provided by Monash University. Note: Materials may be edited for content and length.


Journal Reference:

  1. B. Song, J. C. Niclis, M. A. Alikhan, S. Sakkal, A. Sylvain, P. G. Kerr, A. L. Laslett, C. A. Bernard, S. D. Ricardo. Generation of Induced Pluripotent Stem Cells from Human Kidney Mesangial Cells. Journal of the American Society of Nephrology, 2011; DOI: 10.1681/ASN.2010101022

Cite This Page:

Monash University. "Winding back the clock with kidney stem cells." ScienceDaily. ScienceDaily, 18 May 2011. <www.sciencedaily.com/releases/2011/05/110516102329.htm>.
Monash University. (2011, May 18). Winding back the clock with kidney stem cells. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2011/05/110516102329.htm
Monash University. "Winding back the clock with kidney stem cells." ScienceDaily. www.sciencedaily.com/releases/2011/05/110516102329.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) — It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) — More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) — In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) — The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins