Featured Research

from universities, journals, and other organizations

Novel therapy improves cardiovascular health in central sleep apnea patients

Date:
May 16, 2011
Source:
American Thoracic Society
Summary:
Researchers have demonstrated the effectiveness of a novel treatment that stimulates the nerve that controls the diaphragm to normalize the breathing of patients who suffer from both heart failure and central sleep apnea.

Researchers have demonstrated the effectiveness of a novel treatment that stimulates the nerve that controls the diaphragm to normalize the breathing of patients who suffer from both heart failure and central sleep apnea.

"Many heart failure patients suffer from central sleep apnea, which a number of studies have shown increases mortality in these patients," said Shahrokh Javaheri, MD, professor emeritus of medicine at the University of Cincinnati and medical director of Sleepcare Diagnostics in Mason, Ohio.

Systolic heart failure describes a medical condition in which the heart no longer pumps blood strongly enough to meet the body's needs. According to the American Heart Association, the number of Americans living with heart failure is estimated at 5.8 million -- a number that is expected to grow as people live longer and the population ages. Heart failure is also the leading cause of hospitalization among Medicare patients

Dr. Javaheri and his colleagues presented the results of their study, "Single Night Transvenous Nerve Stimulation Improves Central Sleep Apnea in Systolic Heart Failure Patients," during the ATS 2011 International Conference, in Denver.

In this study, Dr. Javaheri and his colleagues conducted an acute, prospective investigation of 16 patients with a mean age of 59 and a mean body mass index of 27 kg/mk2. All 16 patients were diagnosed with heart failure (mean left ventricular ejection fraction of 30 percent) and central sleep apnea.

The patients served as their own control group, receiving on one night phrenic nerve stimulation and no therapeutic intervention on another. The intervention, which acts like a pacemaker for the nerve, dramatically reduced the number of times patients stopped, or almost stopped, breathing; improved blood oxygenation levels while sleeping; and resulted in a healthier heart rate.

Compared to the control night, phrenic nerve stimulation resulted in the virtual elimination of central sleep apnea as measured by the central apnea Index (25 14 vs. 3 4/hour, p ≤0.001). There was a significant decrease in the apnea-hypopnea index (47 12 vs. 24 15/hour, p=0.002) and in the associated arousal index (32 12 vs. 16 10/hour, p=0.001) and in the reduced number of times the patient experienced 4 percent oxygen desaturation (31 11 vs. 16 12/hour, p=0.002). Overnight sleep heart rate decreased significantly (73.3 17.1 vs. 71.1 16.3 bpm, p=0.002).

The current best treatment for these patients is Continuous Positive Airway Pressure (CPAP). In about half of all patients, CPAP suppresses central sleep apnea and improves cardiovascular health and mortality, according to Dr. Javaheri. However, even among those patients that could be helped by CPAP, many cannot tolerate sleeping an entire night with a nasal mask, so the percentage of patients helped by CPAP is considerably lower.

"Our research suggests," said Dr. Javaheri, "that there is a new therapy -- one that, unlike CPAP and other existing mask-based therapies, could be tolerated by all patients."

Dr. Javaheri added that a randomized clinical trial is now needed to determine the clinical implications on long-term phrenic nerve stimulation on morbidity and mortality of heart failure patients with central sleep apnea.


Story Source:

The above story is based on materials provided by American Thoracic Society. Note: Materials may be edited for content and length.


Cite This Page:

American Thoracic Society. "Novel therapy improves cardiovascular health in central sleep apnea patients." ScienceDaily. ScienceDaily, 16 May 2011. <www.sciencedaily.com/releases/2011/05/110516111648.htm>.
American Thoracic Society. (2011, May 16). Novel therapy improves cardiovascular health in central sleep apnea patients. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2011/05/110516111648.htm
American Thoracic Society. "Novel therapy improves cardiovascular health in central sleep apnea patients." ScienceDaily. www.sciencedaily.com/releases/2011/05/110516111648.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins