Featured Research

from universities, journals, and other organizations

Nasal steroid spray may not help resolve dysfunction of the ear's eustachian tubes

Date:
May 16, 2011
Source:
JAMA and Archives Journals
Summary:
For patients with eustachian tube dysfunction (ETD), steroids administered by a nasal spray may be ineffective, according to a new study.

For patients with eustachian tube dysfunction (ETD), steroids administered by a nasal spray may be ineffective, according to a report in the May issue of Archives of Otolaryngology-Head and Neck Surgery, one of the JAMA/Archives journals.

The eustachian tubes connect the middle ear, the upper part of the throat and the ends of the nasal passages. Eustachian tube dysfunction may contribute to fluid collection in the middle ear (otitis media with effusion, or OME) or negative middle ear pressure (NMEP). Presently there is no gold-standard single treatment for this condition, although one hypothesis proposes that intra-nasal steroid treatment could be beneficial. "Because of the lack of a single accepted medical intervention to deal with ETD and the ostensibly benign nature of this condition, it is common practice for some clinicians to take a 'wait and see' initial approach when this clinical entity is encountered in lieu of prescribing unproven or unapproved medications," note the authors, who also point to the fact that some cases resolve on their own.

Michael B. Gluth, M.D., formerly of the Mayo Clinic in Rochester , Minn. (now with University of Arkansas for Medical Sciences, Little Rock), and coauthors conducted a randomized, placebo-controlled, double-blind prospective clinical trial of intranasal aqueous triamcinolone acetonide for ETD. They enrolled patients, children and adults, ages 6 and older, presenting with either OME or NMEP between September 2005 and December 2008 and randomly assigned 45 patients to the treatment group and 46 to the placebo group. The outcome measures were clinical resolution of ETD, as evidenced by tympanometry (a test of the eardrum's mobility and middle ear conditions), and improvement in symptom scores on a questionnaire administered before and after treatment.

Among adults who had follow-up tympanograms, 18.9 percent of those receiving the study drug and 32.4 percent of those receiving placebo experienced complete normalization. Of pediatric patients with follow-up tympanograms, 7 percent receiving triamcinolone acetonide and 27 percent receiving the placebo had complete normalization. Neither of these differences was statistically significant, nor were overall poststudy symptom scores between the two groups (after prestudy overall symptom score was adjusted for).

The researchers note that the results obtained challenge their original premise. "These findings were contradictory to our hypothesis that nasal steroids would increase the rate of tympanogram normalization," they conclude. "These findings do not support the use of intranasal steroid sprays to treat the manifestations of eustachian tube dysfunction."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. B. Gluth, D. R. McDonald, A. L. Weaver, C. D. Bauch, C. W. Beatty, L. J. Orvidas. Management of Eustachian Tube Dysfunction With Nasal Steroid Spray: A Prospective, Randomized, Placebo-Controlled Trial. Archives of Otolaryngology - Head and Neck Surgery, 2011; 137 (5): 449 DOI: 10.1001/archoto.2011.56

Cite This Page:

JAMA and Archives Journals. "Nasal steroid spray may not help resolve dysfunction of the ear's eustachian tubes." ScienceDaily. ScienceDaily, 16 May 2011. <www.sciencedaily.com/releases/2011/05/110516161934.htm>.
JAMA and Archives Journals. (2011, May 16). Nasal steroid spray may not help resolve dysfunction of the ear's eustachian tubes. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2011/05/110516161934.htm
JAMA and Archives Journals. "Nasal steroid spray may not help resolve dysfunction of the ear's eustachian tubes." ScienceDaily. www.sciencedaily.com/releases/2011/05/110516161934.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins