Featured Research

from universities, journals, and other organizations

Novel gene linked to aging hearts

Date:
May 20, 2011
Source:
University of Ottawa Heart Institute
Summary:
Researchers have identified a novel gene in the nucleus of muscle and brain cells that affects heart development and the aging process. Their investigation brings the promise of new treatments for an old, failing heart.

Researchers at the University of Ottawa Heart Institute (UOHI) have identified a novel gene in the nucleus of muscle and brain cells that affects heart development and the aging process. Their investigation brings the promise of new treatments for an old, failing heart.

"We know that aging is the greatest predictor of cardiovascular disease and heart failure. So we have been working backward in time, looking at the fetal heart to understand changes in the process as it ages, grows frail and fails," said molecular biologist Patrick Burgon, PhD.

A research team led by Burgon discovered the gene in the cell's nucleus -- the site where hereditary information or DNA is housed -- suggesting that it may control the behavior of other genes important in heart development.

The researchers, who focus on the fetal heart as it grows into an adult heart, named the gene MLIP for Muscle enriched A-type Lamin Interacting Protein. Mutations in the Lamin gene family are associated with muscular dystrophy and other degenerative heart muscle diseases.

Their findings have been reported electronically in the Journal of Biological Chemistry and are scheduled for formal publication in June. Researchers now will investigate how animal models respond when the MLIP gene is removed to gain greater knowledge into its function.

"Greater knowledge of this gene and how it works will help us understand loss of cardiac function. Our research opens up new avenues relevant to the characteristics of cardiac development," said Burgon.

At the Heart Institute, studies to identify complex cardiovascular mechanisms are part of a world-wide effort among a core of leading scientific organizations. The Heart Institute collaborates with an international consortium that has already discovered 13 new genes that increase the risk of coronary artery disease (CAD).

Heart Institute researchers previously identified gene 9p21 -- the first genetic risk factor recognized for heart disease and the first major new cardiovascular risk factor since the discovery of cholesterol. The Institute has also located a variety of other genes influencing diseases such as atrial fibrillation and biological processes such as obesity.

Research by Burgon's group was funded by the Heart institute and Canadian Institutes of Health Research.


Story Source:

The above story is based on materials provided by University of Ottawa Heart Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. E. Ahmady, S. A. Deeke, S. Rabaa, L. Kouri, L. Kenney, A. F. R. Stewart, P. G. Burgon. Identification of a novel muscle enriched A-type Lamin interacting protein (MLIP). Journal of Biological Chemistry, 2011; DOI: 10.1074/jbc.M110.165548

Cite This Page:

University of Ottawa Heart Institute. "Novel gene linked to aging hearts." ScienceDaily. ScienceDaily, 20 May 2011. <www.sciencedaily.com/releases/2011/05/110517105804.htm>.
University of Ottawa Heart Institute. (2011, May 20). Novel gene linked to aging hearts. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2011/05/110517105804.htm
University of Ottawa Heart Institute. "Novel gene linked to aging hearts." ScienceDaily. www.sciencedaily.com/releases/2011/05/110517105804.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins