Featured Research

from universities, journals, and other organizations

Developing a preventive vaccine against HIV/AIDS: Study opens new possibilities

Date:
May 23, 2011
Source:
IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer
Summary:
The best hope for reducing the incidence of AIDS is a preventive vaccine. The most effective preventive vaccines act by inducing a response based on neutralizing antibodies. Previous studies have shown that HIV-infected patients can produce a broad neutralizing response. To better understand the induction of neutralizing antibodies in these patients, researchers in Spain have now included samples of patients treated with a low level of viral replication.

The HIV epidemic is the largest in the world and represents one of the most serious public health problems, according to data from the World Health Organization (WHO). Only 30% of the more than 10 million patients in need have the access to the antiretroviral treatment. The total number of infected people exceeds 30 million and there are about 3 million new infections per year. The best hope for reducing the incidence of AIDS (Acquired Immune Deficiency Syndrome) is a preventive vaccine.

The most effective preventive vaccines act by inducing a response based on neutralizing antibodies. Some groups had shown that HIV-infected patients can produce a broad neutralizing response. But so far, all studies have excluded patients on antiretroviral therapy with undetectable viral load, i.e., having an improved profile compared to untreated patients.

To better understand the induction of neutralizing antibodies in these patients, researchers from IDIBAPS/Hospital Clinic of Barcelona, bound to the program HIVACAT (Research Project AIDS Vaccine), for the first time, have included samples of patients treated with a low level of viral replication. 508 samples were analyzed in 364 patients (191 treated and 173 with no antiretroviral treatment) through a new strategy based on the use of recombinant viruses.

The study, published in the Journal of Virology, represents the first big test and evaluation of the neutralization in HIV-infected persons with undetectable viral load. "We have shown that patients receiving antiretroviral treatment are able to induce a broad and strong humoral immune response (broad-spectrum neutralizing antibodies) for HIV despite having undetectable viremia," says the last author of the study, Eloisa Yuste. In these patients, the low level of antigenic stimulation may be compensated by an improved B cell function induced by antiretroviral treatment.

The report concludes that the percentage of treated and untreated patients that generated broad-spectrum neutralizing antibodies was very similar: 2.3%. This is the first step in identifying the epitope able to induce the development of these antibodies and therefore would be an excellent candidate for potential AIDS preventive vaccine based on the development of broad-spectrum neutralizing antibodies. This is how other highly effective preventive vaccines such as them against human papillomavirus, hepatitis A and B and polio, among others.

Neutralizing antibodies do not work when HIV infection is already established. But their presence induced by a vaccine could prevent infection if an uninfected person comes in contact with the virus. So, the next step is to get the induction of broad-spectrum neutralizing antibodies are generated in patients who have not acquired the virus. "The next stages of the research will characterize these broad-spectrum neutralizing antibodies and identify the virus that has led and could serve as a potential preventive vaccine in healthy people," she concludes.


Story Source:

The above story is based on materials provided by IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. Medina-Ramirez, V. Sanchez-Merino, S. Sanchez-Palomino, A. Merino-Mansilla, C. B. Ferreira, I. Perez, N. Gonzalez, A. Alvarez, J. M. Alcocer-Gonzalez, F. Garcia, J. M. Gatell, J. Alcami, E. Yuste. Broadly Cross-Neutralizing Antibodies in HIV-1 Patients with Undetectable Viremia. Journal of Virology, 2011; DOI: 10.1128/JVI.02482-10

Cite This Page:

IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer. "Developing a preventive vaccine against HIV/AIDS: Study opens new possibilities." ScienceDaily. ScienceDaily, 23 May 2011. <www.sciencedaily.com/releases/2011/05/110523091537.htm>.
IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer. (2011, May 23). Developing a preventive vaccine against HIV/AIDS: Study opens new possibilities. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2011/05/110523091537.htm
IDIBAPS - Institut d'Investigacions Biomèdiques August Pi i Sunyer. "Developing a preventive vaccine against HIV/AIDS: Study opens new possibilities." ScienceDaily. www.sciencedaily.com/releases/2011/05/110523091537.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) — A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) — Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) — California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
New Drug Could Reduce Cardiovascular Deaths

New Drug Could Reduce Cardiovascular Deaths

Newsy (Aug. 30, 2014) — The new drug from Novartis could reduce cardiovascular deaths by 20 percent compared to other similar drugs. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins