Featured Research

from universities, journals, and other organizations

New-onset atrial fibrillation in initially healthy women may increase risk of premature death

Date:
May 25, 2011
Source:
JAMA and Archives Journals
Summary:
In a follow-up of participants from the Women's Health Study, seemingly healthy middle-aged women with new-onset atrial fibrillation had an associated increased risk of cardiovascular, non-cardiovascular, and all-cause death, with some of the risk potentially explained by nonfatal cardiovascular events, according to a new study.

In a follow-up of participants from the Women's Health Study, seemingly healthy middle-aged women with new-onset atrial fibrillation had an associated increased risk of cardiovascular, noncardiovascular, and all-cause death, with some of the risk potentially explained by nonfatal cardiovascular events, according to a study in the May 25 issue of JAMA.

"Atrial fibrillation (AF) is the most common cardiac arrhythmia, and its prevalence is markedly increasing over time. Substantial evidence exists that the risk of stroke, congestive heart failure (CHF), and cognitive dysfunction is higher in patients with AF, underscoring the importance of AF as a public health problem. In addition, several studies involving mainly older individuals with and without cardiovascular disease found an increased risk of death in patients with AF," the authors write. "The risks associated with new-onset AF among middle-aged women and populations with a low comorbidity [co-existing illness] burden are poorly defined."

David Conen, M.D., M.P.H., of University Hospital, Basel, Switzerland, and colleagues conducted a study with data from the Women's Health Study to assess the risk of death and cardiovascular events among initially healthy middle-aged women with new-onset AF. Between 1993 and March 2010, 34,722 women participating in the Women's Health Study underwent prospective follow-up. Participants were 95 percent white, older than 45 years (median [midpoint], 53 years), and free of AF and cardiovascular disease at the beginning of the study.

During a median follow-up of 15.4 years, 1,011 women developed AF. Also, there were a total of 1,602 deaths from all causes, including 63 deaths among women in the new onset AF group. The authors' analysis indicated that the age-adjusted relative risk of all-cause, cardiovascular, and noncardiovascular mortality was significantly higher among women with new-onset AF. "Adjustment for nonfatal cardiovascular events potentially on the causal pathway to death attenuated [weakened] these relationships, but new-onset AF remained significantly associated with all mortality components," the authors write. They add that these findings suggest that this increased risk is partly mediated through the occurrence of nonfatal cardiovascular disease, particularly the development of CHF and stroke.

"In this large cohort of initially healthy women at low risk of cardiovascular disease, women with new-onset AF had an increased risk of death and incident cardiovascular events. Because a significant proportion of the excess mortality risk appears attributable to the occurrence of nonfatal cardiovascular events prior to death, there is a potential opportunity to improve the outcome of individuals with new-onset AF through both prevention and optimal management of these associated comorbidities," the authors conclude.

Editorial: Mortality Risk Among Middle-aged Women With First Atrial Fibrillation

In an accompanying editorial, Yoko Miyasaka, M.D., Ph.D., of Kansai Medical University, Hirakata, Japan, and Teresa S. M. Tsang, M.D., of the University of British Columbia, Vancouver, Canada, comment on the findings of this study.

"The report by Conen and colleagues provides compelling evidence that the first detection of AF in otherwise event-free middle-aged women is associated with a significantly increased mortality risk, which may reflect an existing higher cardiovascular risk burden including subclinical structural substrates of AF. Whether treatment of AF including stroke prevention and aggressive management of cardiovascular risk factors can reverse the mortality risk associated with AF among these women awaits future studies."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal References:

  1. D. Conen, C. U. Chae, R. J. Glynn, U. B. Tedrow, B. M. Everett, J. E. Buring, C. M. Albert. Risk of Death and Cardiovascular Events in Initially Healthy Women With New-Onset Atrial Fibrillation. JAMA: The Journal of the American Medical Association, 2011; 305 (20): 2080 DOI: 10.1001/jama.2011.659
  2. Y. Miyasaka, T. S. M. Tsang. Mortality Risk Among Middle-aged Women With First Atrial Fibrillation. JAMA: The Journal of the American Medical Association, 2011; 305 (20): 2116 DOI: 10.1001/jama.2011.699

Cite This Page:

JAMA and Archives Journals. "New-onset atrial fibrillation in initially healthy women may increase risk of premature death." ScienceDaily. ScienceDaily, 25 May 2011. <www.sciencedaily.com/releases/2011/05/110524162011.htm>.
JAMA and Archives Journals. (2011, May 25). New-onset atrial fibrillation in initially healthy women may increase risk of premature death. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2011/05/110524162011.htm
JAMA and Archives Journals. "New-onset atrial fibrillation in initially healthy women may increase risk of premature death." ScienceDaily. www.sciencedaily.com/releases/2011/05/110524162011.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com
How The 'Angelina Jolie Effect' Increased Cancer Screenings

How The 'Angelina Jolie Effect' Increased Cancer Screenings

Newsy (Sep. 19, 2014) Angelina's Jolie's decision to undergo a preventative mastectomy in 2013 inspired many women to seek early screenings for the disease. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins