Featured Research

from universities, journals, and other organizations

Certain biomarkers appear to increase risk of death for elderly patients with heart failure symptoms

Date:
May 24, 2011
Source:
JAMA and Archives Journals
Summary:
Elderly patients with symptoms of heart failure and increased concentrations in the blood of the biomarker copeptin, or a combination of elevated concentrations of copeptin and the biomarker NT-proBNP, had an associated increased risk of all-cause death, according to a new study.

Elderly patients with symptoms of heart failure and increased concentrations in the blood of the biomarker copeptin, or a combination of elevated concentrations of copeptin and the biomarker NT-proBNP, had an associated increased risk of all-cause death, according to a study in the May 25 issue of JAMA.

Related Articles


"A central part in evaluation of elderly patients with symptoms of heart failure is to identify simple tools that can aid the clinician in identifying high-risk and low-risk patients. Combining a biomarker produced locally in the myocardium [the muscle tissue of the heart] with a marker produced centrally in the body may be useful in patients with symptoms of heart failure. Studies have consequently tried to establish the clinical use of different markers in the circulation," the authors write.

One such established marker is B-type natriuretic peptide and the N-terminal fragment of its precursor (NT-proBNP). Vasopressin is a non-cardiac plasma marker of cardiovascular disease. The plasma concentration of vasopressin increases in patients with heart failure and is associated with left ventricular dysfunction. Copeptin has emerged as a potential surrogate marker for measurement of vasopressin concentration and may help identify patients with heart failure at high and low risk of death, according to background information in the article.

Urban Alehagen, M.D., Ph.D., of Linkoping University, Linkoping, Sweden and colleagues evaluated the association of combined measurement of plasma copeptin and NT-proBNP concentrations with mortality in an elderly primary care population with symptoms of heart failure. The study included 470 elderly patients in Sweden with heart failure symptoms between January and December 1996. Clinical examination, echocardiography, and measurement of peptide concentrations were performed, with follow-up through December 2009.

During a median (midpoint) follow-up of 13 years, there were 226 deaths from all causes, including 146 cardiovascular deaths. The mortality distribution across the different measures of copeptin segmented into quartiles (fourths) ranged from 26.5 percent (first quartile) to 46.6 percent (fourth quartile) for cardiovascular mortality and from 38.5 percent (first quartile) to 69.5 percent (fourth quartile) for all-cause mortality. The corresponding distribution for NT-proBNP was 15.9 percent (first quartile) to 56.9 percent (fourth quartile) for cardiovascular mortality and between 28.3 percent (first quartile) to 75.9 percent (fourth quartile) for all-cause mortality.

In models comparing the second, third, and fourth quartiles against the first quartile of the biomarkers, concentrations of copeptin and NT-proBNP were associated with long-term all-cause mortality, both separately and in combination. Similar results were obtained in models examining cardiovascular mortality. Analysis of data showed all-cause mortality associated with different combinations of copeptin and NT-proBNP, from a group with low plasma concentrations of both markers (group 1, with 63.7 percent survival) to a group with a combination of high plasma concentrations of both markers (group 4, with 16.5 percent survival). Prognostic information obtained by the markers was greater when both were combined.

"The objective of this study was to apply markers in a patient group commonly encountered in primary care, i.e., elderly patients who often present with other diseases, making interpretation of symptoms difficult. The original design of our cohort study did not allow us to assess diagnostic elements of biomarker measurement. Instead, we focused solely on the prognostic information of the markers when applied in a primary care population. These data, together with our findings of the prognostic information provided by measurement of copeptin concentrations in elderly patients with symptoms of heart failure, suggest that vasopressin may be a potential target for therapeutic intervention."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. U. Alehagen, U. Dahlstrom, J. F. Rehfeld, J. P. Goetze. Association of Copeptin and N-Terminal proBNP Concentrations With Risk of Cardiovascular Death in Older Patients With Symptoms of Heart Failure. JAMA: The Journal of the American Medical Association, 2011; 305 (20): 2088 DOI: 10.1001/jama.2011.666

Cite This Page:

JAMA and Archives Journals. "Certain biomarkers appear to increase risk of death for elderly patients with heart failure symptoms." ScienceDaily. ScienceDaily, 24 May 2011. <www.sciencedaily.com/releases/2011/05/110524162013.htm>.
JAMA and Archives Journals. (2011, May 24). Certain biomarkers appear to increase risk of death for elderly patients with heart failure symptoms. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2011/05/110524162013.htm
JAMA and Archives Journals. "Certain biomarkers appear to increase risk of death for elderly patients with heart failure symptoms." ScienceDaily. www.sciencedaily.com/releases/2011/05/110524162013.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins