Featured Research

from universities, journals, and other organizations

Fat burning increases in men with oral form of bronchodilator drug, formoterol, study finds

Date:
June 6, 2011
Source:
The Endocrine Society
Summary:
Formoterol, a medication used to treat asthma and other lung diseases, improves fat burning and protein metabolism in men, a new study finds.

Formoterol, a medication used to treat asthma and other lung diseases, improves fat burning and protein metabolism in men, a new study finds.

Related Articles


The results are being presented at The Endocrine Society's 93rd Annual Meeting in Boston.

"Research in animals has shown that formoterol can stimulate the growth of muscle and the burning of fat. This is the first study demonstrating the beneficial metabolic effects of formoterol in humans," said the study's lead author Paul Lee, MD, PhD, a research fellow at the Garvan Institute of Medical Research in Sydney.

The discovery is important, Lee said, because "it suggests that formoterol may be used in the future to prevent obesity and muscle loss in humans."

With funding from the National Health Medical Research Council Australia, Lee and colleagues studied the drug in eight healthy men over one week. All men had a healthy weight and received a low daily dose of formoterol in a pill, Lee said. To find the optimal dose, the authors studied three doses in four of the men: 80, 160 or 320 micrograms per day. He said they found that the 160-microgram dose had metabolic benefits without raising heart rate.

All eight men underwent metabolic testing before and after treatment with 160 micrograms daily of formoterol. One week of formoterol treatment increased metabolism in the men by more than 10 percent, according to an estimate of the resting energy expenditure (the calories needed at rest during 24 hours). The rate of fat oxidation, or burning, rose by almost 25 percent, indicating there may be a loss of fat in the long term, Lee reported.

Additionally, the researchers determined the rate of protein burning before and after treatment.

"Protein is the building block for muscle in the body," Lee explained. "Burning less protein means preservation of muscle and may increase muscle mass in the long term."

After formoterol treatment the protein burning rate fell close to 15 percent, he said. They used the leucine turnover technique, which tracks the synthesis and breakdown of the amino acid leucine. According to Lee, it is the most accurate method of estimating protein metabolism in humans.

Lee said none of the volunteers reported any major side effects from the 160-microgram dose. Tachycardia, or fast heart rate, is a known side effect of older medications in the same drug class as formoterol, especially at high doses. Low dose formoterol, similar to the one used in this clinical study, resulted in no substantial adverse cardiac effects in animal studies, he said.

"Our results call for further research to investigate whether formoterol improves body composition, physical health and function," Lee said.


Story Source:

The above story is based on materials provided by The Endocrine Society. Note: Materials may be edited for content and length.


Cite This Page:

The Endocrine Society. "Fat burning increases in men with oral form of bronchodilator drug, formoterol, study finds." ScienceDaily. ScienceDaily, 6 June 2011. <www.sciencedaily.com/releases/2011/06/110606092742.htm>.
The Endocrine Society. (2011, June 6). Fat burning increases in men with oral form of bronchodilator drug, formoterol, study finds. ScienceDaily. Retrieved December 26, 2014 from www.sciencedaily.com/releases/2011/06/110606092742.htm
The Endocrine Society. "Fat burning increases in men with oral form of bronchodilator drug, formoterol, study finds." ScienceDaily. www.sciencedaily.com/releases/2011/06/110606092742.htm (accessed December 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Healthier Lifestyles Could Prevent 4 In 10 Cancer Cases

Healthier Lifestyles Could Prevent 4 In 10 Cancer Cases

Newsy (Dec. 26, 2014) If patients had led healthier lifestyles, Cancer Research UK found about 40 percent of cancer cases could have been prevented. Video provided by Newsy
Powered by NewsLook.com
FDA Issues New Warning About Pure Caffeine Powder Usage

FDA Issues New Warning About Pure Caffeine Powder Usage

Newsy (Dec. 24, 2014) The FDA cites two deaths this year linked to pure caffeine powder as warnings of the potentially fatal substance. Video provided by Newsy
Powered by NewsLook.com
Alarming CDC Lab Report Reveals Ebola Sample Mix-Up

Alarming CDC Lab Report Reveals Ebola Sample Mix-Up

Newsy (Dec. 24, 2014) The Centers for Disease Control and Prevention released a report claiming a lab tech in Atlanta might have been exposed to the Ebola virus. Video provided by Newsy
Powered by NewsLook.com
French General Physicians Begin Strike, ER Doctors Back to Work

French General Physicians Begin Strike, ER Doctors Back to Work

AFP (Dec. 23, 2014) French doctors went on strike Tuesday in protest at an upcoming health bill. Emergency room doctors on the other end are returning to work after reaching an historic agreement. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins