Featured Research

from universities, journals, and other organizations

Type 2 diabetes associated with increased risk of stroke and cardiovascular problems, but metabolic syndrome is not

Date:
June 14, 2011
Source:
JAMA and Archives Journals
Summary:
Among patients who have had an ischemic stroke or transient ischemic attack (TIA), type 2 diabetes was associated with an increased risk of recurrent stroke or cardiovascular events, but metabolic syndrome was not, according to a new study.

Among patients who have had an ischemic stroke or transient ischemic attack (TIA), type 2 diabetes was associated with an increased risk of recurrent stroke or cardiovascular events, but metabolic syndrome was not, according to a report published Online First by Archives of Neurology, one of the JAMA/Archives journals.

Previous research has examined the association between cardiovascular incidents and these conditions, according to background information in the article. "Type 2 diabetes mellitus is associated with increased risks of both stroke and coronary heart disease (CHD)," the authors write. "Metabolic syndrome (MetS) or insulin resistance identifies individuals at higher risk for developing type 2 diabetes and is also associated with an increase in stroke and cardiovascular morbidity."

Alfred Callahan, M.D., from Vanderbilt University, Nashville, and colleagues evaluated these risks as part of a secondary analysis of the Stroke Prevention by Aggressive Reduction of Cholesterol Levels (SPARCL) Trial. The primary goal of that study was to evaluate the effect of a cholesterol-lowering statin drug (atorvastatin) on reducing the incidence of stroke in patients with a prior stroke or TIA. For this study, the authors performed a secondary analysis on the data to determine the risk of recurrent stroke or cardiovascular events in patients with type 2 diabetes or MetS, and whether atorvastatin affected those risks.

In total, the study included 4,731 participants who had experienced an ischemic stroke or TIA. When enrollment began, researchers classified 794 individuals as having type 2 diabetes, 642 as having MetS and the remaining 3,295 as having neither condition. The endpoints used for this analysis were recurrence of stroke, major coronary or cardiovascular events, any CHD event and any revascularization procedure (a procedure, such as angioplasty, to open a blocked artery).

Patients with type 2 diabetes were more likely than those in the control group to experience another stroke, major cardiovascular incident, or revascularization procedure. Those in the MetS group were not at increased risk of stroke or major cardiovascular events, but were more likely than those in the control group to undergo revascularization procedures. Treatment with the statin medication did significantly reduce the risk of these events in participants with type 2 diabetes or MetS.

The authors note that their results are similar to other studies of stroke and cardiovascular events in individuals with MetS or type 2 diabetes. In particular, they cite the differences in risks between the two conditions. They also point out that statin use did seem to be protective for participants: "Although the possibility of variation in the benefit of statin treatment in subjects with or without type 2 diabetes or MetS cannot be excluded by this analysis, there was no evidence of a difference in treatment effect."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Alfred Callahan; Pierre Amarenco; Larry B. Goldstein; Henrik Sillesen; Mike Messig; Gregory P. Samsa; Irfan Altafullah; Lucy Y. Ledbetter; Mary J. MacLeod; Russell Scott; Michael Hennerici; Justin A. Zivin; K. Michael A. Welch; for the SPARCL Investigators. Risk of Stroke and Cardiovascular Events After Ischemic Stroke or Transient Ischemic Attack in Patients With Type 2 Diabetes or Metabolic Syndrome: Secondary Analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Trial. Archives of Neurology, 2011; DOI: 10.1001/archneurol.2011.146

Cite This Page:

JAMA and Archives Journals. "Type 2 diabetes associated with increased risk of stroke and cardiovascular problems, but metabolic syndrome is not." ScienceDaily. ScienceDaily, 14 June 2011. <www.sciencedaily.com/releases/2011/06/110613162055.htm>.
JAMA and Archives Journals. (2011, June 14). Type 2 diabetes associated with increased risk of stroke and cardiovascular problems, but metabolic syndrome is not. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2011/06/110613162055.htm
JAMA and Archives Journals. "Type 2 diabetes associated with increased risk of stroke and cardiovascular problems, but metabolic syndrome is not." ScienceDaily. www.sciencedaily.com/releases/2011/06/110613162055.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins