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False negative tests in breast cancer may lead to wrong drug choice, study finds

Date:
June 28, 2011
Source:
Yale University
Summary:
A team of researchers has confirmed that between 10 and 20 percent of breast cancers classified as estrogen receptor negative are really positive. Understanding when and why breast cancers may be misclassified has important implications for treatment and outcomes for women diagnosed with breast cancer.
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A team of Yale Cancer Center researchers has confirmed that between 10-20% of breast cancers classified as Estrogen Receptor (ER) negative are really positive. Understanding when and why breast cancers may be misclassified has important implications for treatment and outcomes for women diagnosed with breast cancer.

Its findings are published online in the June 28 Journal of Clinical Oncology.

A woman diagnosed with breast cancer can be tested by immunohistochemistry (IHC), a process that detects the presence of specific proteins in cancer tissue. Those who test positive for ER are prescribed an endocrine therapy, like Tamoxifen, Letrazol or a similar drug. The 10-20% of cancer patients who are incorrectly classified as ER negative may be treated with less effective therapies.

Led by David Rimm, M.D., professor of pathology at Yale School of Medicine, the research team highlighted the limitations of IHC in the assessment of Estrogen Receptor in breast cancer and defined a new method for standardizing ER measurement. It used a novel method to detect the estrogen receptor that uses fluorescent detection in conjunction with a series of standard controls. The team reported that this more sensitive and reproducible method finds cases initially called "negative" that behave as "positive."

"Our research shows that the conventional methods of measurement of Estrogen Receptor may result in a 10-20% false negative rate," said Rimm. "This may be leading to under-treatment of breast cancer patients and we may be missing the opportunity to use one of our best drugs (Tamoxifen) due to inadequate testing."

The assay has been licensed to HistoRx Inc. of Branford, Conn. The test will soon be available to patients in Clinical Laboratory Improvement Amendments-certified labs. The first lab to release the test will be Genoptix Inc. based in Carlsbad, California.

Other authors on the study include Allison Welsh, Sudha Kumar, Peter Gershkovich and Malini Harigopal.


Story Source:

The above post is reprinted from materials provided by Yale University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Allison W. Welsh, Christopher B. Moeder, Sudha Kumar, Peter Gershkovich, Elaine T. Alarid, Malini Harigopal, Bruce G. Haffty, David L. Rimm. Standardization of Estrogen Receptor Measurement in Breast Cancer Suggests False-Negative Results Are a Function of Threshold Intensity Rather Than Percentage of Positive Cells. Journal of Clinical Oncology, 2011; DOI: 10.1200/JCO.2010.32.9706

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Yale University. "False negative tests in breast cancer may lead to wrong drug choice, study finds." ScienceDaily. ScienceDaily, 28 June 2011. <www.sciencedaily.com/releases/2011/06/110627162825.htm>.
Yale University. (2011, June 28). False negative tests in breast cancer may lead to wrong drug choice, study finds. ScienceDaily. Retrieved July 30, 2015 from www.sciencedaily.com/releases/2011/06/110627162825.htm
Yale University. "False negative tests in breast cancer may lead to wrong drug choice, study finds." ScienceDaily. www.sciencedaily.com/releases/2011/06/110627162825.htm (accessed July 30, 2015).

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