Featured Research

from universities, journals, and other organizations

Natural gases as a therapy for heart disease?

Date:
June 29, 2011
Source:
The Peninsula College of Medicine and Dentistry
Summary:
An understanding of the interaction between hydrogen sulphide (the 'rotten eggs' gas) and nitric oxide, both naturally occurring in the body, could lead to the development of new therapies and interventions to treat heart failure. Researchers have analyzed the complex "cross talk" between hydrogen sulfide and nitric oxide, both gasses that occur naturally in the body, and found that the interaction may offer potential strategies in the management of heart failure.

An understanding of the interaction between hydrogen sulphide (the 'rotten eggs' gas) and nitric oxide, both naturally occurring in the body, could lead to the development of new therapies and interventions to treat heart failure.

Related Articles


Research carried out by scientists from the Peninsula Medical School at the University of Exeter and the National University of Singapore has analysed the complex 'cross talk' between hydrogen sulphide (H2S ) and nitric oxide (NO), both gasses that occur naturally in the body, and found that the interaction may offer potential strategies in the management of heart failure.

The research is published in the leading international journal Antioxidants and Redox Signaling.

Both gases interact naturally with each other within the body and the balance between the two and other chemical compounds has influence on health. The research team found that by modulating how H2S and NO interact, a positive affect was produced for heart health.

The two gases were found to interact together to form a thiol-sensitive compound (linked to the sulphur in H2S) which produces inotropic (muscular contraction) and lusitropic (muscular relaxation) effects in the heart. This crosstalk suggests that there is the potential to produce a molecule that may be of benefit to the heart and which could be the basis of a new drug therapy based on elements that occur naturally in the body.

The study also offers a new perspective on gaseous neurotransmitters, in which the function of cells is influenced by the interaction of the two gases.

Prof. Matt Whiteman, joint author from the Peninsula Medical School, commented: "Our findings are potentially very exciting and offer a novel insight into understanding how and why the heart fails. This could lead to new treatment and management strategies of heart failure, such as molecules which release H2S. By altering the ratio of H2S and NO, two naturally occurring physiological gases in the heart and perhaps the rest of the cardiovascular system, we have the potential to manipulate heart and vascular function. There is huge potential in the continued development of H2S delivery systems either through pharmacological means or through dietary intervention."


Story Source:

The above story is based on materials provided by The Peninsula College of Medicine and Dentistry. Note: Materials may be edited for content and length.


Journal Reference:

  1. Qian-Chen Yong, Jia Ling Cheong, Fei Hua, Lih-Wen Deng, Yok Moi Khoo, How-Sung Lee, Alexis Perry, Mark Wood, Matthew Whiteman, Jin-Song Bian. Regulation of Heart Function by Endogenous Gaseous Mediators—Crosstalk Between Nitric Oxide and Hydrogen Sulfide. Antioxidants & Redox Signaling, 2011; 14 (11): 2081 DOI: 10.1089/ars.2010.3572

Cite This Page:

The Peninsula College of Medicine and Dentistry. "Natural gases as a therapy for heart disease?." ScienceDaily. ScienceDaily, 29 June 2011. <www.sciencedaily.com/releases/2011/06/110629102147.htm>.
The Peninsula College of Medicine and Dentistry. (2011, June 29). Natural gases as a therapy for heart disease?. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2011/06/110629102147.htm
The Peninsula College of Medicine and Dentistry. "Natural gases as a therapy for heart disease?." ScienceDaily. www.sciencedaily.com/releases/2011/06/110629102147.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins