Featured Research

from universities, journals, and other organizations

Researchers identify early biomarker for future atopy in asymptomatic children

Date:
July 6, 2011
Source:
American Thoracic Society
Summary:
The signs of atopy may be present long before symptoms begin, even in month-old babies, according to a new research study from Denmark. The study found that the level of urinary eosinophil protein-X, a marker of inflammatory cells, in newborn babies was linked to higher risk of allergic sensitization, nasal eosinophilia and eczema at six years.

The signs of atopy may be present long before symptoms begin, even in month-old babies, according to a new research study from Denmark. The study found that the level of urinary eosinophil protein-X (u-EPX), a marker of inflammatory cells, in newborn babies was linked to higher risk of allergic sensitization, nasal eosinophilia and eczema at six years.

The study appeared online in advance of the print publication of the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

"We asked whether the allergic disease process may be active prior to the development of symptoms, and if so, whether there are biomarkers that could be clinically useful in predicting the development of disease," said principle investigator Hans Bisgaard, MD, DMSci, professor of pediatrics at the University of Copenhagen. "We found that in babies born to asthmatic mothers, urine levels of eosinophil protein-X may predict the development of allergic symptoms."

The researchers measured the levels of u-EPX and several other markers of inflammation in 369 healthy month-old infants who were enrolled in the Copenhagen Prospective Study on Asthma in Childhood (COPSAC), a birth cohort study of symptom-free month-old children born to asthmatic mothers.

The children were evaluated for allergic sensitization to 16 common inhalant and food allergens at 6 months, 18 months, 4 years and 6 years. Their blood eosinophil count was also taken at these intervals. Nasal eosinophilia was investigated by nasal scraping in the child's sixth year of life, and allergic rhinitis was diagnosed by age six based on interviews of parents and the child's history of symptoms. Asthma-like symptoms, and diagnoses of asthma and eczema were also noted.

In the first year of life, four percent of the children developed asthma-like symptoms and more than one-quarter (27 percent) were diagnosed with eczema. Another 17 percent went on to develop asthma-like symptoms and 15 percent developed eczema by age six.

When the researchers analyzed the data for associations between infant levels of u-EPX and future symptoms and diagnoses, they found that elevated u-EPX at one month was associated with 49 percent increase in risk of allergic sensitization, an association that was statistically significant for both food and aeroallergens. High u-EPX was also associated with a three-fold risk of developing nasal eosinophilia, indicating allergic inflammation of the upper airways. Finally, infants whose u-EPX was in the top quartile had a 40 percent greater risk for developing eczema by the age of six than those in the lower three quartiles.

"These data suggest that there is early life eosinophilic activation prior to symptom debut in children developing atopy-related conditions," said Dr. Bisgaard. "The mechanism behind the apparent pre-symptom eosinophilic activation in very young children is still unknown, but this study suggests that there is an ongoing pathogenesis in these children that begins well before symptom onset and includes the activation of eosinophil granulocytes."

Dr. Bisgaard noted that the current findings support similar findings of previous studies done in the same cohort. "These findings are in line with our previous studies, one where we saw increased concentration of exhaled nitric oxide in the breath of these healthy babies preceding later development of lung symptoms, and one that showed an association between bacterial colonization in the airways and later risk of asthma. Together, these three studies support the concept that a disease process is present long before symptoms become present -- 'a patient is a patient before he is diagnosed as a patient' -- and that the disease originates very early in life," he said.

"This knowledge may help us identify the highest risk groups of children from a very early age for targeted prevention as well as individualized intervention and treatment," he continued. "This has redirected our research into what causes asthma, eczema and allergy, and we are now focusing on events in the first months of life or before birth."


Story Source:

The above story is based on materials provided by American Thoracic Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. B. L. K. Chawes, K. Bonnelykke, H. Bisgaard. Elevated Eosinophil Protein X in Urine from Healthy Neonates Precedes Development of Atopy in the First 6 Years of Life. American Journal of Respiratory and Critical Care Medicine, 2011; DOI: 10.1164/rccm.201101-0111OC

Cite This Page:

American Thoracic Society. "Researchers identify early biomarker for future atopy in asymptomatic children." ScienceDaily. ScienceDaily, 6 July 2011. <www.sciencedaily.com/releases/2011/07/110706104804.htm>.
American Thoracic Society. (2011, July 6). Researchers identify early biomarker for future atopy in asymptomatic children. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2011/07/110706104804.htm
American Thoracic Society. "Researchers identify early biomarker for future atopy in asymptomatic children." ScienceDaily. www.sciencedaily.com/releases/2011/07/110706104804.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins