Featured Research

from universities, journals, and other organizations

SUMO defeats protein aggregates that typify Parkinson’s disease

Date:
July 11, 2011
Source:
Rockefeller University Press
Summary:
A small protein called SUMO might prevent the protein aggregations that typify Parkinson's disease (PD), according to a new study.

Unsumoylated alpha-synuclein aggregates into fibrils (right), whereas sumoylated alpha-synuclein doesn't (left). New research in the Journal of Cell Biology suggests that sumoylation might prevent the protein aggregations that typify Parkinson’s disease.
Credit: Krumova, P., et al. 2011. J. Cell Biol. doi:10.1083/jcb.201010117

A small protein called SUMO might prevent the protein aggregations that typify Parkinson's disease (PD), according to a new study in the July 11, 2011, issue of The Journal of Cell Biology.

Related Articles


Insoluble protein clusters are the hallmarks of several neurodegenerative diseases. In PD, neurons harbor insoluble clumps of the protein alpha-synuclein. What triggers these protein pileups remains obscure. A possible clue for PD came when researchers overexpressed alpha-synuclein in human kidney cells and found that the protein was modified by the addition of the small, ubiquitin-like molecule SUMO. Since sumoylation generally boosts the solubility of proteins, the result raised the possibility that SUMO proteins affect the aggregation of alpha-synuclein.

Researchers tested whether sumoylating purified alpha-synuclein hindered its clustering into fibrils, filaments similar to those detected in neurons of PD patients. If all of the alpha-synuclein molecules in a solution were sumoylated, no fibrils appeared. And even if only 10 percent of the molecules were sumoylated, fibril formation slowed dramatically.

SUMO molecules typically attach to two sites on alpha-synuclein, the researchers found. Compared with controls, cells that produced alpha-synuclein variants lacking these two sites contained more protein clusters and were more likely to die by apoptosis. The scientists then genetically altered rats to manufacture the alpha-synuclein variants specifically in neurons. Cell death surged in the substantia nigra, the brain region where large numbers of neurons perish in PD patients. But whether sumoylation goes awry in these patients remains unknown.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. P. Krumova, E. Meulmeester, M. Garrido, M. Tirard, H.-H. Hsiao, G. Bossis, H. Urlaub, M. Zweckstetter, S. Kugler, F. Melchior, M. Bahr, J. H. Weishaupt. Sumoylation inhibits α-synuclein aggregation and toxicity. The Journal of Cell Biology, 2011; 194 (1): 49 DOI: 10.1083/jcb.201010117

Cite This Page:

Rockefeller University Press. "SUMO defeats protein aggregates that typify Parkinson’s disease." ScienceDaily. ScienceDaily, 11 July 2011. <www.sciencedaily.com/releases/2011/07/110711131322.htm>.
Rockefeller University Press. (2011, July 11). SUMO defeats protein aggregates that typify Parkinson’s disease. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2011/07/110711131322.htm
Rockefeller University Press. "SUMO defeats protein aggregates that typify Parkinson’s disease." ScienceDaily. www.sciencedaily.com/releases/2011/07/110711131322.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins