Featured Research

from universities, journals, and other organizations

Discovery throws light on blood pressure regulation

Date:
July 29, 2011
Source:
Biotechnology and Biological Sciences Research Council
Summary:
Researchers have discovered that a protein found in the walls of blood vessels plays a key role in maintaining healthy blood pressure -- a discovery that could one day lead to new treatments for people with high blood pressure.

Researchers have discovered that a protein found in the walls of blood vessels plays a key role in maintaining healthy blood pressure -- a discovery that could one day lead to new treatments for people with high blood pressure.

The research, funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and the British Heart Foundation (BHF), shows that malfunction of the protein -- a potassium channel called Kv7.4 -- contributes to the maintenance of high blood pressure. The discovery is published in the journal Circulation.

Dr Iain Greenwood from St George's, University of London led the study. He said "High blood pressure is one of the most common diagnoses in the UK and one in three adults has it -- that's around 16 million people. People with high blood pressure are at much greater risk of heart attack, heart failure, and kidney disease and it's the main risk factor for stroke.

"We are trying to understand how our bodies go about regulating our blood pressure under normal circumstances -- the more we understand, the better we can get at spotting what is going wrong and intervening when someone has this common chronic health issue. This discovery is an important part of the puzzle and might one day lead to new treatments."

Dr Greenwood and his team have shown that Kv7.4 plays an essential role in maintaining the extent to which arteries are constricted or dilated. He said "We have to be able to change our blood pressure at the drop of a hat -- quite literally! If you dropped your hat and bent over to pick it up, you body would automatically reduce your blood pressure to account for the position of your head relative to your heart and the effect of gravity and then when you stood up again, your body would adjust it back up.

"The muscles in the walls of your blood vessels play a role in adjusting blood pressure and if they need to increase it, they squeeze the blood vessels more tightly to literally put mechanical pressure on your blood."

The researchers examined rodents that had high blood pressure and discovered that in some cases the Kv7.4 channels weren't working properly. These channels allow the passage of potassium out of the muscle cells in our blood vessels and they have to be open and closed at the right times so that the muscles can contract or relax when we need them to. In the animals that had high blood pressure and malfunctioning Kv7.4 channels, the problem was that the channels were blocked. This caused an imbalance in the finely controlled chemical environment of the muscle cell.

"The problem is," continued Dr Greenwood, "if the Kv7.4 channels cannot function, the muscle cells overreact to the signals the body is giving to increase blood pressure. We think that in the animals we studied the redundant Kv7.4 channels contributed markedly to their high blood pressure."

Whilst it is extremely unlikely that most people with high blood pressure have defective Kv7.4 channels, the researchers hope that by understanding the key role they play in maintaining healthy blood pressure we can use this knowledge to develop new strategies for adjusting blood pressure using drug treatments in the future.

Professor Douglas Kell, Chief Executive, BBSRC said "If we are to have long, healthy lives, we need to understand how our bodies cope with the demands we place on them. Increasing our knowledge of the biology that underpins normal, healthy processes will pave the way for future strategies to prevent or treat health problems. Maintaining healthy blood pressure is an important part of keeping us all well and so this research could be of great benefit to many people in the future."

Professor Jeremy Pearson, Associate Medical Director at the British Heart Foundation, said "Physical activity, maintaining a healthy weight, reducing the amount of salt and alcohol you consume, and increasing the amount of fruit and vegetables you eat can all play a part in lowering your risk of having high blood pressure. However, we still do not fully understand what causes the condition in most people -- and current medicines to treat it are often not fully effective. Crucial research such as this could lead to new medical treatments for high blood pressure."


Story Source:

The above story is based on materials provided by Biotechnology and Biological Sciences Research Council. Note: Materials may be edited for content and length.


Journal Reference:

  1. T. A. Jepps, P. S. Chadha, A. J. Davis, M. I. Harhun, G. W. Cockerill, S. P. Olesen, R. S. Hansen, I. A. Greenwood. Downregulation of Kv7.4 Channel Activity in Primary and Secondary Hypertension. Circulation, 2011; DOI: 10.1161/CIRCULATIONAHA.111.032136

Cite This Page:

Biotechnology and Biological Sciences Research Council. "Discovery throws light on blood pressure regulation." ScienceDaily. ScienceDaily, 29 July 2011. <www.sciencedaily.com/releases/2011/07/110711164531.htm>.
Biotechnology and Biological Sciences Research Council. (2011, July 29). Discovery throws light on blood pressure regulation. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2011/07/110711164531.htm
Biotechnology and Biological Sciences Research Council. "Discovery throws light on blood pressure regulation." ScienceDaily. www.sciencedaily.com/releases/2011/07/110711164531.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins