Featured Research

from universities, journals, and other organizations

Seven in one blow: Scientists discover DNA regions influencing prostate cancer risk

Date:
July 12, 2011
Source:
Helmholtz Association of German Research Centres
Summary:
Scientists are studying the genetic risks for prostate cancer. The researchers have discovered seven DNA regions for which an association with an increased prostate cancer risk has now been established for the first time.

Doctors have known for a long time that prostate cancer "runs in the family." Men with relatives who have been diagnosed with prostate cancer have an elevated risk of also developing this type of cancer. It was only last year that DKFZ scientists calculated that this risk rises with the number of affected direct family members and also depends on the relatives' age at outbreak of the disease.

Related Articles


The exact DNA variants that contribute to prostate cancer risk have now been published by an international research consortium with participation of scientists from the German Cancer Research Center. In a multi-stage study, the collaborators systematically searched the whole genome of cancer patients and healthy controls for specific gene variants. Then they calculated whether specific variants are found more often in patients than in healthy people.

Professor Dr. Hermann Brenner, one of the DKFZ researchers participating in the consortium, explains: "Each of these gene variants taken on its own is associated with only a slight increase in prostate cancer risk by a few percent. However, by taking account of the different variants at the same time it becomes possible to identify groups of persons who have a significantly elevated risk. Examining the genetic material for such risk variants might therefore improve medical consultation on the prevention and early detection of prostate cancer in the future."

Such DNA variants are scientifically called single nucleotide polymorphisms (SNPs). They are defined as a single variation of a nucleotide which occurs with varying frequency in the whole population. If a relationship in numbers is found between a particular SNP and cancer incidence, researchers conclude that a gene within the affected DNA region plays a role in cancer.

The first two study stages conducted by the consortium had already identified 16 SNPs in 16 different DNA regions to be associated with an elevated prostate cancer risk. Together with the results of prior association studies, about 30 risk genes for prostate cancer were known then. In the third and last round the research consortium searched in 4,574 cancer patients and 4,164 controls for another 1,536 SNPs. The emerging associations with cancer risk were then verified once more using 51,311 DNA samples of cancer patients and healthy men.

Alongside a number of already identified variants, the investigators found seven SNPs that emerged for the first time in association with an elevation in prostate cancer risk. The variants are all located in DNA regions that also contain genes for which the scientists consider it plausible that they play a role in carcinogenesis. However, an association with the malignancy of cancer could not be established for any of these variants. With the seven newly discovered DNA regions, scientists are now able to explain about 25 percent of familial cancer risk.


Story Source:

The above story is based on materials provided by Helmholtz Association of German Research Centres. Note: Materials may be edited for content and length.


Journal Reference:

  1. Zsofia Kote-Jarai et al. Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Nature Genetics, 2011; DOI: 10.1038/ng.882

Cite This Page:

Helmholtz Association of German Research Centres. "Seven in one blow: Scientists discover DNA regions influencing prostate cancer risk." ScienceDaily. ScienceDaily, 12 July 2011. <www.sciencedaily.com/releases/2011/07/110712094158.htm>.
Helmholtz Association of German Research Centres. (2011, July 12). Seven in one blow: Scientists discover DNA regions influencing prostate cancer risk. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2011/07/110712094158.htm
Helmholtz Association of German Research Centres. "Seven in one blow: Scientists discover DNA regions influencing prostate cancer risk." ScienceDaily. www.sciencedaily.com/releases/2011/07/110712094158.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Americans Drink More in the Winter

Americans Drink More in the Winter

Buzz60 (Dec. 22, 2014) The BACtrack breathalyzer app analyzed Americans' blood alcohol content and found out a whole lot of interesting things about their drinking habits. Mara Montalbano (@maramontalbano) has more. Video provided by Buzz60
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins