July 15, 2011 The widely known PSA blood test for prostate cancer in men may get a second life as a much-needed new test for breast cancer, the most common form of cancer in women worldwide, scientists are reporting in a new study in the American Chemical Society's journal Analytical Chemistry.
Chien Chou and colleagues say that the prostate-specific antigen (PSA) measured in the test also is a potential biomarker of breast cancer in women. However, levels of PSA in healthy women are usually so small that only ultrasensitive tests can measure them.
To improve PSA detection in women, the researchers built a tiny fiber-optic biosensor using gold nanoparticles and PSA antibodies to detect and report PSA levels via a fluorescent signal. The biosensor's sensitivity (its ability to detect elevated PSA levels in cases of breast cancer) and its specificity (how well it avoids false predictions of breast cancer) are comparable to those found in using PSA as a biomarker for prostate cancer. "Furthermore, these values may compare favorably with the sensitivity and specificity of the current screening methods for breast cancer such as clinical examination… and mammogram," the scientists report.
The authors acknowledge funding from Chang Gung University, Chang Gung Memorial Hospital, and the National Science Council of Taiwan.
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- Ying-Feng Chang, Shuo-Hui Hung, Yi-Jang Lee, Ran-Chou Chen, Li-Chen Su, Chao-Sung Lai, Chien Chou. Discrimination of Breast Cancer by Measuring Prostate-Specific Antigen Levels in Women's Serum. Analytical Chemistry, 2011; 83 (13): 5324 DOI: 10.1021/ac200754x
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