Featured Research

from universities, journals, and other organizations

Computer simulations aid understanding of bacterial resistance against commonly used antibiotics

Date:
July 22, 2011
Source:
Public Library of Science
Summary:
A recent study into the interactions between aminoglycoside antibiotics and their target site in bacteria used computer simulations to elucidate this mechanism and thereby suggest drug modifications.

A recent study into the interactions between aminoglycoside antibiotics and their target site in bacteria used computer simulations to elucidate this mechanism and thereby suggest drug modifications.

In the article, which will be published on July 21st in the open-access journal PLoS Computational Biology, researchers from University of Warsaw, Poland, and University of California San Diego, USA, describe their study of the physical basis of one bacterial resistance mechanism -- mutations of the antibiotic target site, namely RNA of the bacterial ribosome. They performed simulations and observed changes in the interaction between the antibiotic and the target site when different mutations were introduced.

In hospitals throughout the world, aminoglycosidic antibiotics are used to combat even the most severe bacterial infections, being very successful especially against tuberculosis and plague. However, the continuous emergence of resistant bacteria has created an urgent need to improve these antibiotics. Previous experiments on bacteria have shown that specific point mutations in the bacterial ribosomal RNA confer high resistance against aminoglycosides. However, the physico-chemical mechanism underlying this effect has not been known. Using computer simulations the researchers explained how various mutations in this specific RNA fragment influence its dynamics and lead to resistance.

Bacteria have developed other ways of gaining resistance, not just through mutations, and further studies are underway. The authors are now investigating the resistance mechanism by which bacterial enzymes actively modify and neutralize aminoglycosidic antibiotics. These molecular modeling studies together with experiments could help to design even better aminoglycoside derivatives in the future.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Julia Romanowska, J. Andrew McCammon, Joanna Trylska. Understanding the Origins of Bacterial Resistance to Aminoglycosides through Molecular Dynamics Mutational Study of the Ribosomal A-Site. PLoS Computational Biology, 2011; 7 (7): e1002099 DOI: 10.1371/journal.pcbi.1002099

Cite This Page:

Public Library of Science. "Computer simulations aid understanding of bacterial resistance against commonly used antibiotics." ScienceDaily. ScienceDaily, 22 July 2011. <www.sciencedaily.com/releases/2011/07/110721172330.htm>.
Public Library of Science. (2011, July 22). Computer simulations aid understanding of bacterial resistance against commonly used antibiotics. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2011/07/110721172330.htm
Public Library of Science. "Computer simulations aid understanding of bacterial resistance against commonly used antibiotics." ScienceDaily. www.sciencedaily.com/releases/2011/07/110721172330.htm (accessed July 23, 2014).

Share This




More Plants & Animals News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Michigan Plant's Goal: Flower and Die

Michigan Plant's Goal: Flower and Die

AP (July 22, 2014) An 80-year-old agave plant, which is blooming for the first and only time at a University of Michigan conservatory, will die when it's done (July 22) Video provided by AP
Powered by NewsLook.com
San Diego Zoo Welcomes New, Rare Rhino Calf

San Diego Zoo Welcomes New, Rare Rhino Calf

Reuters - US Online Video (July 21, 2014) An endangered black rhino baby is the newest resident at the San Diego Zoo. Sasha Salama reports. Video provided by Reuters
Powered by NewsLook.com
Shark Sightings a Big Catch for Cape Tourism

Shark Sightings a Big Catch for Cape Tourism

AP (July 21, 2014) A rise in shark sightings along the shores of Chatham, Massachusetts is driving a surge of eager vacationers to the beach town looking to catch a glimpse of a great white. (July 21) Video provided by AP
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins