Featured Research

from universities, journals, and other organizations

New protein structure model to inhibit cancer

Date:
July 28, 2011
Source:
University of Hertfordshire
Summary:
Researchers in the UK have developed a new structural model of a protein, which makes it possible to develop more effective drugs to target diseases such as cancer, heart disease and influenza.

Researchers at the University of Hertfordshire have developed a new structural model of a protein, which makes it possible to develop more effective drugs to target diseases such as cancer, heart disease and influenza.

Related Articles


In a paper which being published in the Journal of Structural Biology online, a research team lead by Dr Andreas Kukol at the University's School of Life Sciences, describes how they have developed a new 3D model of a protein which unleashes the inhibition of the growth of cells which, unless stunted, could lead to the spread of cancer or support infections such as influenza.

"Our bodies are made up of proteins and therefore they are important for the proper functioning of the body," said Dr Kukol. "Malfunction of the protein can lead to cancer. This happens when it becomes over active, so our task has been to identify inhibitors."

A research team led by Dr Kukol developed a 3D model of the kinase IKK-β enzyme which is a protein that regulates other proteins.

"This enzyme controls proteins like policeman controls traffic," said Dr Kukol. "If the policeman or the enzyme gets out of control, then there will be chaos."

The new 3D model can be used to find new inhibitors, such as organic molecules like aspirin that attach to the active site of the enzyme and make it less active thus stopping the spread of cancer or influenza.

The model is now ready for pharmaceutical companies to adopt so that they can develop more effective drugs to target these conditions.

Dr Kukol explained that the comparative modeling and computer simulation methods they used for this protein may be taken up by other research groups. In that way protein structure modelling could lead to more accurate models in the future.

A copy of Dr Kukol's paper Structure and dynamics of the kinase IKK-β -- a key regulator of the NF-kappa B transcription factor is available from Hιlθne Murphy (details below).


Story Source:

The above story is based on materials provided by University of Hertfordshire. Note: Materials may be edited for content and length.


Journal Reference:

  1. Munishikha Kalia, Andreas Kukol. Structure and dynamics of the kinase IKK-β – a key regulator of the NF-kappa B transcription factor. Journal of Structural Biology, 2011; DOI: 10.1016/j.jsb.2011.07.012

Cite This Page:

University of Hertfordshire. "New protein structure model to inhibit cancer." ScienceDaily. ScienceDaily, 28 July 2011. <www.sciencedaily.com/releases/2011/07/110728082410.htm>.
University of Hertfordshire. (2011, July 28). New protein structure model to inhibit cancer. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2011/07/110728082410.htm
University of Hertfordshire. "New protein structure model to inhibit cancer." ScienceDaily. www.sciencedaily.com/releases/2011/07/110728082410.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Matter & Energy News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Navy Unveils Robot Fish

Navy Unveils Robot Fish

Reuters - Light News Video Online (Dec. 18, 2014) — The U.S. Navy unveils an underwater device that mimics the movement of a fish. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
3D Printed Cookies Just in Time for Christmas

3D Printed Cookies Just in Time for Christmas

Reuters - Innovations Video Online (Dec. 18, 2014) — A tech company in Spain have combined technology with cuisine to develop the 'Foodini', a 3D printer designed to print the perfect cookie for Santa. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com
First Etihad Superjumbo Flight in December

First Etihad Superjumbo Flight in December

AFP (Dec. 18, 2014) — The first flight of Etihad Airways' long-awaited Airbus A380 superjumbo will take place later in December, the Abu Dhabi carrier said Thursday, also announcing its first Boeing 787 Dreamliner route. Duration: 01:09 Video provided by AFP
Powered by NewsLook.com
Ford Expands Air Bag Recall Nationwide

Ford Expands Air Bag Recall Nationwide

Newsy (Dec. 18, 2014) — The automaker added 447,000 vehicles to its recall list, bringing the total to more than 502,000. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins