Featured Research

from universities, journals, and other organizations

Aging: T cells that survive the longest may better protect against infections such as the flu

Date:
August 3, 2011
Source:
University of Arizona Health Sciences Center
Summary:
Aging brings about a selective decline in the numbers and function of T cells -- a type of white blood cell involved in the immune system's response to infection -- and T cells that survive the longest may better protect against infections such as the flu, according to a new study. The finding may lead to targeting these cells with vaccinations that increase their number and improve protection against disease in older adults.

Aging brings about a selective decline in the numbers and function of T cells -- a type of white blood cell involved in the immune system's response to infection -- and T cells that survive the longest may better protect against infections such as the flu, according to a study led by researchers from the University of Arizona College of Medicine -- Tucson. The finding may lead to targeting these cells with vaccinations that increase their number and improve protection against disease in older adults.

Related Articles


The study results are reported in the Aug. 1 Early Edition issue of the Proceedings of the National Academy of Sciences.

The decline in immune function with age is viewed as the most important contributing factor to older adults' increased susceptibility to infections and decreased responses to vaccinations. Improving T cell function can result in improved immunity.

"We have discovered that aging brings about selective attrition of those T cells that defend us against new infections that we have not encountered before. Not all T cells age the same and the ones that will survive the longest have special features that may allow them to best protect against infections such as flu," says study senior author Janko Nikolich-Žugich, MD, PhD, chairman of the Department of Immunobiology, co-director of the Arizona Center on Aging, and Elizabeth Bowman Professor in Medical Research at the UA College of Medicine, and a member of the UA BIO5 Institute. "We now know that there are a few good cells that can be targeted by vaccination to expand their numbers and achieve protection.

Finding ways to expand them is our next and final challenge, and our team at the Arizona Center on Aging should be able to achieve that in the next few years."

The article is entitled, "Non-random attrition of the naοve CD8+ T-cell pool with aging governed by TCR:pMHC interactions."


Story Source:

The above story is based on materials provided by University of Arizona Health Sciences Center. Note: Materials may be edited for content and length.


Cite This Page:

University of Arizona Health Sciences Center. "Aging: T cells that survive the longest may better protect against infections such as the flu." ScienceDaily. ScienceDaily, 3 August 2011. <www.sciencedaily.com/releases/2011/08/110801160224.htm>.
University of Arizona Health Sciences Center. (2011, August 3). Aging: T cells that survive the longest may better protect against infections such as the flu. ScienceDaily. Retrieved February 1, 2015 from www.sciencedaily.com/releases/2011/08/110801160224.htm
University of Arizona Health Sciences Center. "Aging: T cells that survive the longest may better protect against infections such as the flu." ScienceDaily. www.sciencedaily.com/releases/2011/08/110801160224.htm (accessed February 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, February 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Hikers Rescued After Fall from Oregon Mountain

Hikers Rescued After Fall from Oregon Mountain

AP (Feb. 1, 2015) — Two climbers who were hurt in a fall on Mount Hood are now being treated for their injuries. Rescue officials say they were airlifted off the mountain Saturday afternoon by an Oregon National Guard helicopter. (Feb. 2) Video provided by AP
Powered by NewsLook.com
Smart Glasses Augment Reality to Help Visually Impaired

Smart Glasses Augment Reality to Help Visually Impaired

Reuters - Innovations Video Online (Feb. 1, 2015) — New augmented reality smart glasses developed by researchers at Oxford University can help people with visual impairments improve their vision by providing depth-based feedback, allowing users to "see" better. Joel Flynn reports. Video provided by Reuters
Powered by NewsLook.com
Flu Season Hitting Elderly Hard

Flu Season Hitting Elderly Hard

Reuters - US Online Video (Jan. 31, 2015) — The CDC says this year&apos;s flu season is hitting people 65 years of age and older especially hard. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) — The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins