Featured Research

from universities, journals, and other organizations

Aging: T cells that survive the longest may better protect against infections such as the flu

Date:
August 3, 2011
Source:
University of Arizona Health Sciences Center
Summary:
Aging brings about a selective decline in the numbers and function of T cells -- a type of white blood cell involved in the immune system's response to infection -- and T cells that survive the longest may better protect against infections such as the flu, according to a new study. The finding may lead to targeting these cells with vaccinations that increase their number and improve protection against disease in older adults.

Aging brings about a selective decline in the numbers and function of T cells -- a type of white blood cell involved in the immune system's response to infection -- and T cells that survive the longest may better protect against infections such as the flu, according to a study led by researchers from the University of Arizona College of Medicine -- Tucson. The finding may lead to targeting these cells with vaccinations that increase their number and improve protection against disease in older adults.

The study results are reported in the Aug. 1 Early Edition issue of the Proceedings of the National Academy of Sciences.

The decline in immune function with age is viewed as the most important contributing factor to older adults' increased susceptibility to infections and decreased responses to vaccinations. Improving T cell function can result in improved immunity.

"We have discovered that aging brings about selective attrition of those T cells that defend us against new infections that we have not encountered before. Not all T cells age the same and the ones that will survive the longest have special features that may allow them to best protect against infections such as flu," says study senior author Janko Nikolich-Žugich, MD, PhD, chairman of the Department of Immunobiology, co-director of the Arizona Center on Aging, and Elizabeth Bowman Professor in Medical Research at the UA College of Medicine, and a member of the UA BIO5 Institute. "We now know that there are a few good cells that can be targeted by vaccination to expand their numbers and achieve protection.

Finding ways to expand them is our next and final challenge, and our team at the Arizona Center on Aging should be able to achieve that in the next few years."

The article is entitled, "Non-random attrition of the naοve CD8+ T-cell pool with aging governed by TCR:pMHC interactions."


Story Source:

The above story is based on materials provided by University of Arizona Health Sciences Center. Note: Materials may be edited for content and length.


Cite This Page:

University of Arizona Health Sciences Center. "Aging: T cells that survive the longest may better protect against infections such as the flu." ScienceDaily. ScienceDaily, 3 August 2011. <www.sciencedaily.com/releases/2011/08/110801160224.htm>.
University of Arizona Health Sciences Center. (2011, August 3). Aging: T cells that survive the longest may better protect against infections such as the flu. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2011/08/110801160224.htm
University of Arizona Health Sciences Center. "Aging: T cells that survive the longest may better protect against infections such as the flu." ScienceDaily. www.sciencedaily.com/releases/2011/08/110801160224.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Fungus Killing Bats, Spreading in US

Deadly Fungus Killing Bats, Spreading in US

AP (Apr. 24, 2014) — A disease that has killed more than six million cave-dwelling bats in the United States is on the move and wildlife biologists are worried. White Nose Syndrome, discovered in New York in 2006, has now spread to 25 states. (April 24) Video provided by AP
Powered by NewsLook.com
Companies Ramp Up Wellness to Lower Health Costs

Companies Ramp Up Wellness to Lower Health Costs

AP (Apr. 24, 2014) — That little voice telling you to exercise, get in shape and get healthy is probably coming from your boss. More companies are beefing up wellness programs to try and cut down their health care costs. (April 24) Video provided by AP
Powered by NewsLook.com
FDA Wants To Ban Sales Of E-Cigarettes To Minors

FDA Wants To Ban Sales Of E-Cigarettes To Minors

Newsy (Apr. 24, 2014) — The Food and Drug Administration wants to crack down on the use of e-cigarettes, banning the sale of the product to minors. Video provided by Newsy
Powered by NewsLook.com
Michigan Man Sees Thanks to 'bionic Eye'

Michigan Man Sees Thanks to 'bionic Eye'

AP (Apr. 23, 2014) — A legally blind Michigan man is 'seeing something new every day' thanks to a high-tech retinal implant procedure. He's one of the first in the country to receive a 'bionic eye' since the federal government approved the surgery. (April 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins