Featured Research

from universities, journals, and other organizations

Aging: T cells that survive the longest may better protect against infections such as the flu

Date:
August 3, 2011
Source:
University of Arizona Health Sciences Center
Summary:
Aging brings about a selective decline in the numbers and function of T cells -- a type of white blood cell involved in the immune system's response to infection -- and T cells that survive the longest may better protect against infections such as the flu, according to a new study. The finding may lead to targeting these cells with vaccinations that increase their number and improve protection against disease in older adults.

Aging brings about a selective decline in the numbers and function of T cells -- a type of white blood cell involved in the immune system's response to infection -- and T cells that survive the longest may better protect against infections such as the flu, according to a study led by researchers from the University of Arizona College of Medicine -- Tucson. The finding may lead to targeting these cells with vaccinations that increase their number and improve protection against disease in older adults.

The study results are reported in the Aug. 1 Early Edition issue of the Proceedings of the National Academy of Sciences.

The decline in immune function with age is viewed as the most important contributing factor to older adults' increased susceptibility to infections and decreased responses to vaccinations. Improving T cell function can result in improved immunity.

"We have discovered that aging brings about selective attrition of those T cells that defend us against new infections that we have not encountered before. Not all T cells age the same and the ones that will survive the longest have special features that may allow them to best protect against infections such as flu," says study senior author Janko Nikolich-Žugich, MD, PhD, chairman of the Department of Immunobiology, co-director of the Arizona Center on Aging, and Elizabeth Bowman Professor in Medical Research at the UA College of Medicine, and a member of the UA BIO5 Institute. "We now know that there are a few good cells that can be targeted by vaccination to expand their numbers and achieve protection.

Finding ways to expand them is our next and final challenge, and our team at the Arizona Center on Aging should be able to achieve that in the next few years."

The article is entitled, "Non-random attrition of the naοve CD8+ T-cell pool with aging governed by TCR:pMHC interactions."


Story Source:

The above story is based on materials provided by University of Arizona Health Sciences Center. Note: Materials may be edited for content and length.


Cite This Page:

University of Arizona Health Sciences Center. "Aging: T cells that survive the longest may better protect against infections such as the flu." ScienceDaily. ScienceDaily, 3 August 2011. <www.sciencedaily.com/releases/2011/08/110801160224.htm>.
University of Arizona Health Sciences Center. (2011, August 3). Aging: T cells that survive the longest may better protect against infections such as the flu. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2011/08/110801160224.htm
University of Arizona Health Sciences Center. "Aging: T cells that survive the longest may better protect against infections such as the flu." ScienceDaily. www.sciencedaily.com/releases/2011/08/110801160224.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) — Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) — The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) — Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) — New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins