Featured Research

from universities, journals, and other organizations

Basis for battery-powered skin patch for wider range of protein-based medicines

Date:
August 3, 2011
Source:
American Chemical Society
Summary:
Scientists have confirmed the feasibility of using a new drug delivery system -- the basis for a battery-powered skin patch -- to administer medication that shows promise for treating peripheral artery disease and healing stubborn skin ulcers and burns. The needle-free delivery of the medication, which cannot be given by mouth, can have side effects when injected.

Scientists have confirmed the feasibility of using a new drug delivery system -- the basis for a battery-powered skin patch -- to administer medication that shows promise for treating peripheral artery disease (PAD) and healing stubborn skin ulcers and burns. The needle-free delivery of the medication, which cannot be given by mouth and can have side effects when injected, is reported in the ACS journal, Molecular Pharmaceutics.

Yogeshvar Kalia and colleagues explain that the medication consists of fibroblast growth factors (FGFs), proteins that have shown promise for treating skin conditions and PAD, which causes pain in the legs, buttocks, and feet due to blocked arteries in the legs. However, FGFs become inactive if given by mouth, and their injection can result in kidney and eye damage. The scientists had previously shown that a drug delivery technology called transdermal iontophoresis can deliver medicines made from small proteins. But would the technique, which involves encouraging medicine through the skin with a small electric current, work for larger proteins like FGFs?

Their laboratory tests with samples of human skin and pig skin showed that iontophoresis did work -- in contrast, no FGF was delivered without electricity. Four times more medication remained in the skin than passed through which was also an advantage. Most importantly, the medicine remained biologically active in the skin. The results confirm the feasibility of using iontophoresis to deliver medicines consisting of larger proteins, including FGFs, the scientists note.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. Dubey, R. Perozzo, L. Scapozza, Y. N. Kalia. Noninvasive Transdermal Iontophoretic Delivery of Biologically Active Human Basic Fibroblast Growth Factor. Molecular Pharmaceutics, 2011; 8 (4): 1322 DOI: 10.1021/mp200125j

Cite This Page:

American Chemical Society. "Basis for battery-powered skin patch for wider range of protein-based medicines." ScienceDaily. ScienceDaily, 3 August 2011. <www.sciencedaily.com/releases/2011/08/110803102851.htm>.
American Chemical Society. (2011, August 3). Basis for battery-powered skin patch for wider range of protein-based medicines. ScienceDaily. Retrieved April 21, 2014 from www.sciencedaily.com/releases/2011/08/110803102851.htm
American Chemical Society. "Basis for battery-powered skin patch for wider range of protein-based medicines." ScienceDaily. www.sciencedaily.com/releases/2011/08/110803102851.htm (accessed April 21, 2014).

Share This



More Health & Medicine News

Monday, April 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins