Featured Research

from universities, journals, and other organizations

Genetic 'signature' discovered in plaque, possible key to future treatment

Date:
August 5, 2011
Source:
American Heart Association
Summary:
Researchers have found differences in artery plaque in people who had stroke and people who didn't. These differences -- found in the genetic profile of each plaque -- could allow researchers to target treatments to plaques that are most likely to rupture and cause a heart attack or stroke.

Italian researchers may have identified a genetic "signature" for dangerous plaque that leads to stroke.

Reporting from their study published in Stroke: Journal of the American Heart Association, the researchers said a pattern of five microscopic bits of genetic material called microRNAs (miRNAs) -- a genetic "signature" -- were present only in the plaque from patients who had experienced a stroke.

This is the first report to suggest that miRNAs may provide an important clue about which plaque in artery walls is the most dangerous.

Plaque is made up of fat, cholesterol, calcium and other things found in the blood. Plaque can be "stable" or "unstable." Some remains as a bump or streak on the artery wall and others cause clots that lead to a heart attack or stroke.

Researchers studied 31 patients who had plaque build-up but had not had a stroke and 22 patients who had plaque and had experienced a stroke. They looked for miRNAs.

MicroRNAs are shorter molecular chains than messenger RNA, which take the genetic information contained within the DNA and allow it to be turned into proteins with various functions. MicroRNAs don't translate genetic information, but they bind to the longer messenger RNAs and act as an "on/off" switch to help regulate protein production.

By identifying the specific miRNA signature, researchers hope to find new ways to prevent and treat stroke. For example, new medicines can be designed to hone in on plaques with the potential to rupture.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Journal Reference:

  1. Francesco Cipollone, Lara Felicioni, Riccardo Sarzani, Sante Ucchino, Francesco Spigonardo, Claudia Mandolini, Sara Malatesta, Marco Bucci, Chiara Mammarella, Donato Santovito, Federica De Lutiis, Antonio Marchetti, Andrea Mezzetti, Fiamma Buttitta. A Unique MicroRNA Signature Associated With Plaque Instability in Humans. Stroke, 2011; DOI: 10.1161/STROKEAHA.110.597575

Cite This Page:

American Heart Association. "Genetic 'signature' discovered in plaque, possible key to future treatment." ScienceDaily. ScienceDaily, 5 August 2011. <www.sciencedaily.com/releases/2011/08/110804170030.htm>.
American Heart Association. (2011, August 5). Genetic 'signature' discovered in plaque, possible key to future treatment. ScienceDaily. Retrieved September 14, 2014 from www.sciencedaily.com/releases/2011/08/110804170030.htm
American Heart Association. "Genetic 'signature' discovered in plaque, possible key to future treatment." ScienceDaily. www.sciencedaily.com/releases/2011/08/110804170030.htm (accessed September 14, 2014).

Share This



More Health & Medicine News

Sunday, September 14, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com
Shocker: Journalists Are Utterly Addicted To Coffee

Shocker: Journalists Are Utterly Addicted To Coffee

Newsy (Sep. 13, 2014) A U.K. survey found that journalists consumed the most amount of coffee, but that's only the tip of the coffee-related statistics iceberg. Video provided by Newsy
Powered by NewsLook.com
Contagious Respiratory Illness Continues to Spread Across U.S.

Contagious Respiratory Illness Continues to Spread Across U.S.

Reuters - US Online Video (Sep. 12, 2014) Hundreds of children in several states have been stricken by a serious respiratory illness that is spreading across the U.S. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Batters Sierra Leone Economy Too

Ebola Batters Sierra Leone Economy Too

Reuters - Business Video Online (Sep. 12, 2014) The World Health Organisation warns that local health workers in West Africa can't keep up with Ebola - and among those countries hardest hit by the outbreak, the economic damage is coming into focus, too. As David Pollard reports, Sierra Leone admits that growth in one of the poorest economies in the region is taking a beating. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins