Featured Research

from universities, journals, and other organizations

Genetic 'signature' discovered in plaque, possible key to future treatment

Date:
August 5, 2011
Source:
American Heart Association
Summary:
Researchers have found differences in artery plaque in people who had stroke and people who didn't. These differences -- found in the genetic profile of each plaque -- could allow researchers to target treatments to plaques that are most likely to rupture and cause a heart attack or stroke.

Italian researchers may have identified a genetic "signature" for dangerous plaque that leads to stroke.

Reporting from their study published in Stroke: Journal of the American Heart Association, the researchers said a pattern of five microscopic bits of genetic material called microRNAs (miRNAs) -- a genetic "signature" -- were present only in the plaque from patients who had experienced a stroke.

This is the first report to suggest that miRNAs may provide an important clue about which plaque in artery walls is the most dangerous.

Plaque is made up of fat, cholesterol, calcium and other things found in the blood. Plaque can be "stable" or "unstable." Some remains as a bump or streak on the artery wall and others cause clots that lead to a heart attack or stroke.

Researchers studied 31 patients who had plaque build-up but had not had a stroke and 22 patients who had plaque and had experienced a stroke. They looked for miRNAs.

MicroRNAs are shorter molecular chains than messenger RNA, which take the genetic information contained within the DNA and allow it to be turned into proteins with various functions. MicroRNAs don't translate genetic information, but they bind to the longer messenger RNAs and act as an "on/off" switch to help regulate protein production.

By identifying the specific miRNA signature, researchers hope to find new ways to prevent and treat stroke. For example, new medicines can be designed to hone in on plaques with the potential to rupture.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Journal Reference:

  1. Francesco Cipollone, Lara Felicioni, Riccardo Sarzani, Sante Ucchino, Francesco Spigonardo, Claudia Mandolini, Sara Malatesta, Marco Bucci, Chiara Mammarella, Donato Santovito, Federica De Lutiis, Antonio Marchetti, Andrea Mezzetti, Fiamma Buttitta. A Unique MicroRNA Signature Associated With Plaque Instability in Humans. Stroke, 2011; DOI: 10.1161/STROKEAHA.110.597575

Cite This Page:

American Heart Association. "Genetic 'signature' discovered in plaque, possible key to future treatment." ScienceDaily. ScienceDaily, 5 August 2011. <www.sciencedaily.com/releases/2011/08/110804170030.htm>.
American Heart Association. (2011, August 5). Genetic 'signature' discovered in plaque, possible key to future treatment. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2011/08/110804170030.htm
American Heart Association. "Genetic 'signature' discovered in plaque, possible key to future treatment." ScienceDaily. www.sciencedaily.com/releases/2011/08/110804170030.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins