Featured Research

from universities, journals, and other organizations

Antibiotic useful for localized treatment of bone wear

Date:
August 10, 2011
Source:
Wayne State University
Summary:
Total joint replacement surgeries can help relieve joint pain common in people with conditions like osteoarthritis. But sometimes, the debris from prosthetic joints leads to aseptic loosening, or disintegration of surrounding bones. In 2009, a researcher determined that the anti-inflammatory antibiotic erythromycin can prevent and treat such disintegration. There was one caveat, however: there are side effects associated with long-term usage of erythromycin. Now a biomedical engineer has found a solution.

Total joint replacement surgeries can help relieve joint pain common in people with conditions like osteoarthritis. But sometimes, the debris from prosthetic joints leads to aseptic loosening, or disintegration of surrounding bones. In 2009, a Wayne State University researcher determined that the anti-inflammatory antibiotic erythromycin can prevent and treat such disintegration. There was one caveat, however: there are side effects associated with long-term usage of erythromycin.

But Weiping Ren, M.D., Ph.D., associate professor of biomedical engineering in WSU's College of Engineering, has found a solution. Erythromycin can be administered directly at the site of bone breakdown, rather than orally, so the whole body is not affected. The details of Ren's study are published in the August 2011 issue of Clinical Orthopaedics and Related Research.

"Although oral erythromycin reportedly inhibits inflammation in patients with aseptic loosening, long-term systematic (oral) erythromycin treatment is not recommended," said Ren.

Used primarily for its antimicrobial properties, erythromycin is used to treat conditions like respiratory tract infections and whooping cough, both caused by harmful bacteria. In addition to fighting bacteria, erythromycin reduces inflammation, making it a successful treatment for aseptic loosening.

"But long-term systemic use of erythromycin raises concerns about various side effects, including bacterial resistance, liver damage and gastrointestinal discomfort," said Ren. "We hypothesized that it may be advantageous to restrict erythromycin delivery to the inflammatory tissue around the implant to avoid these side effects."

To test his idea, Ren implanted metal pins coated with erythromycin in the inflamed tissue surrounding the prosthetic joint. He measured bone growth and implant stability, both indicators of how well the prosthesis integrates with the bone, and analyzed microscopic images of the periprosthetic tissue -- the affected tissue surrounding the prosthesis.

Ren found that at very low doses -- about a quarter of the dose used for killing bacteria -- erythromycin effectively reduces aseptic loosening inflammation. "At the same time, we confirmed that oral erythromycin can be effectively delivered into the periprosthetic tissues, supporting our hypothesis that oral erythromycin can be used as one of the nonsurgical treatment methods to extend implant longevity," said Ren.

By extending implant longevity, localized erythromycin will safely treat aseptic loosening and reduce the likelihood that patients with the condition will need revision surgery. "Medical insurance costs will be greatly reduced, because revision surgery is much more expensive than primary surgery," said Ren.

Ren collaborated with David C. Markel, M.D., chairman of the Detroit Medical Center-Providence Hospital orthopaedic residency program and chief of orthopaedic surgery at Providence Hospital in Southfield, Mich.

The current study was funded by the Orthopaedic Research and Education Foundation. Ren also received funding through the Blue Cross Blue Shield of Michigan Foundation's McDevitt Excellence in Research Award for his 2009 study published in Bone.


Story Source:

The above story is based on materials provided by Wayne State University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Weiping Ren, David C. Markel. Emerging Ideas: Can Erythromycin Reduce the Risk of Aseptic Loosening? Clinical Orthopaedics and Related Researchฎ, 2011; 469 (8): 2399 DOI: 10.1007/s11999-011-1918-7

Cite This Page:

Wayne State University. "Antibiotic useful for localized treatment of bone wear." ScienceDaily. ScienceDaily, 10 August 2011. <www.sciencedaily.com/releases/2011/08/110809092038.htm>.
Wayne State University. (2011, August 10). Antibiotic useful for localized treatment of bone wear. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2011/08/110809092038.htm
Wayne State University. "Antibiotic useful for localized treatment of bone wear." ScienceDaily. www.sciencedaily.com/releases/2011/08/110809092038.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) — Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) — Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) — A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins