Featured Research

from universities, journals, and other organizations

New genetic links to MS also play roles in other autoimmune diseases

Date:
August 10, 2011
Source:
Yale University
Summary:
Results of the largest genomics study of multiple sclerosis patients ever undertaken have identified more than two dozen new genetic variants linked to disease risk, including some previously implicated in other autoimmune diseases.

Results of the largest genomics study of multiple sclerosis patients ever undertaken have identified more than two dozen new genetic variants linked to disease risk, including some previously implicated in other autoimmune diseases.

The study, conducted by an international consortium of researchers from the Yale School of Medicine and 129 other institutions, appears in the Aug. 11 issue of the journal Nature. Common genetic links between multiple autoimmune diseases were also confirmed in a second study by Yale and Harvard University researchers in a second study published contemporaneously in the journal PLoS Genetics.

"We have known for some time that many devastating diseases of the immune system must have common genetic causes," said Chris Cotsapas, assistant professor of neurology and genetics at Yale and lead author of the PLoS paper. "Now we have the outline of a map that tells us where we can look for common treatments."

In the Nature study, researchers studied the DNA from 9,772 individuals with multiple sclerosis and 17,376 unrelated healthy controls. They were able to confirm 23 previously known genetic associations and identified a further 29 new genetic variants as well as five strongly suspected of conferring susceptibility to the disease.

A large number of the genes implicated by these findings play pivotal roles in the workings of the immune system, specifically in the function of T-cells, which mount an immune response against foreign substances in the body, and interleukins, chemicals that facilitate interactions between different types of immune cells. One-third of the genes identified in this research have previously been implicated in playing a role in other autoimmune diseases such as Crohn's disease and Type 1 diabetes.

The PLoS research paper found that nearly half of the 107 genetic variants previously linked to an autoimmune disease are also found in at least one other autoimmune disease, such as MS, Crohn's disease, psoriasis, rheumatoid arthritis, lupus, celiac disease and Type 1 diabetes.

"These findings will help focus future research to find new ways to intervene in the course of MS and other diseases," said Yale's David Hafler, the Gilbert H. Glaser Professor of Neurology and professor of immunobiology, chair of the department of neurology and an author on both papers.

Authors of the Nature paper are the International Multiple Sclerosis Genetics Consortium along with the Wellcome Trust Case Control Consortium 2, which brought together hundreds of scientists from 130 institutions to help conduct this ground-breaking genome-wide analysis of patients with MS. The IMSGC was founded by Hafler while he was at the Harvard Medical School and the Broad Institute, along with Alastair Compston of the University of Cambridge and Stephen Hauser from the University of San Francisco.

"Our research settles a longstanding debate on what happens first in the complex sequence of events that leads to disability in multiple sclerosis, and has important implications for future treatment strategies," said Compston, a senior author of the work.

While it is clear that these common genetic variations are one critical component underlying the multiple sclerosis, environmental factors also play a role in the onset of the disease. For instance, previous research has shown vitamin D deficiency may lead to increased risk of MS.

"It is not that there are bad genes or necessarily a bad environment, but instead a disconnection between the interaction of genes with the environment," Hafler said.

The National Institutes of Neurologic Disorders and Stroke of the National Institutes of Health and the National Multiple Sclerosis Society also provided key funding for both studies.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Journal References:

  1. Chris Cotsapas, Benjamin F. Voight, Elizabeth Rossin, Kasper Lage, Benjamin M. Neale, Chris Wallace, Gonηalo R. Abecasis, Jeffrey C. Barrett, Timothy Behrens, Judy Cho, Philip L. De Jager, James T. Elder, Robert R. Graham, Peter Gregersen, Lars Klareskog, Katherine A. Siminovitch, David A. van Heel, Cisca Wijmenga, Jane Worthington, John A. Todd, David A. Hafler, Stephen S. Rich, Mark J. Daly. Pervasive Sharing of Genetic Effects in Autoimmune Disease. PLoS Genetics, 2011; 7 (8): e1002254 DOI: 10.1371/journal.pgen.1002254
  2. Stephen Sawcer et al. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature, 2011; 476 (7359): 214 DOI: 10.1038/nature10251

Cite This Page:

Yale University. "New genetic links to MS also play roles in other autoimmune diseases." ScienceDaily. ScienceDaily, 10 August 2011. <www.sciencedaily.com/releases/2011/08/110810132848.htm>.
Yale University. (2011, August 10). New genetic links to MS also play roles in other autoimmune diseases. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2011/08/110810132848.htm
Yale University. "New genetic links to MS also play roles in other autoimmune diseases." ScienceDaily. www.sciencedaily.com/releases/2011/08/110810132848.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) — The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) — Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) — Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

More Coverage


Multiple Sclerosis Research Doubles Number of Genes Associated With the Disease, Increasing the Number to Over 50

Aug. 10, 2011 — Scientists have identified 29 new genetic variants linked to multiple sclerosis, providing key insights into the biology of a very debilitating neurological ... read more
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:  

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile iPhone Android Web
    Follow Facebook Twitter Google+
    Subscribe RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins