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Uncovering the spread of deadly cancer: New imaging device enables scientists to see tumor cells traveling in the brain

Date:
August 26, 2011
Source:
Case Western Reserve University
Summary:
For the first time, scientists can see pathways to stop a deadly brain cancer in its tracks. Researchers have imaged individual cancer cells and the routes they travel as the tumor spreads.

A first-of-a-kind look at the brain cancer, glioblastoma multiforme, was obtained using a new imaging technique at Case Western Reserve University School of Medicine. The main tumor is green, blood vessels feeding the tumor are red and migrating cells, yellow.
Credit: Case Western Reserve University School of Medicine

For the first time, scientists can see pathways to stop a deadly brain cancer in its tracks. Researchers at Case Western Reserve University School of Medicine have imaged individual cancer cells and the routes they travel as the tumor spreads.

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The researchers used a novel cryo-imaging technique to obtain the unprecedented look at a mouse model of glioblastoma multiforme, a particularly aggressive cancer that has no treatments to stop it from spreading.

A description of their work, and images, is being published Sept. 1 in the journal Cancer Research.

"We're able to see things we couldn't before, and we can use these images to understand how tumor cells invade and disperse," said Susann M. Brady-Kalnay, a professor of molecular biology and microbiology at the Case Western Reserve School of Medicine, and senior author of the paper.

That information, in turn, can be used to help develop and test the effectiveness of drugs and other therapies used to treat the cancer, she said.

To obtain the view, the scientists used a model that included four different cell lines of brain cancers at various stages of tumor development and dispersion. The cancer cells were modified with fluorescent markers and implanted in the model's brain in collaboration with Biomedical Engineering Professor James Basilion's lab.

The cryo-imaging system, developed by David Wilson, also a professor of biomedical engineering at Case Western Reserve, disassembles the brain layer by layer and reassembles the model into a color three-dimensional digital image.

Using software and algorithms designed by the researchers, they are able to differentiate the main tumor mass, the blood vessels that feed the cancer and dispersing cells. The imaging system enables them to peer at single cells and see exactly where they are in the brain.

The lead researchers, Susan Burden-Gulley, Mohammed Qutaish and Kristin Sullivant, found that two cell lines, a human brain cancer LN229, and a rodent cancer CNS-1, best resemble the actions of glioblastoma multiforme in human patients.

Reconstructions of models of those two lines enabled the researchers to analyze the extent and patterns of cancer cell migration and dispersal from tumors along blood vessels and white matter tracts within the brain.

The ability to produce such clear and detailed images, the researchers say, will be invaluable when evaluating the potency of drugs and other therapies designed to block dispersal of glioblastoma multiforme cells.


Story Source:

The above story is based on materials provided by Case Western Reserve University. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. M. Burden-Gulley, M. Q. Qutaish, K. E. Sullivant, H. Lu, J. Wang, S. E. L. Craig, J. P. Basilion, D. L. Wilson, S. M. Brady-Kalnay. Novel Cryo-Imaging of the Glioma Tumor Microenvironment Reveals Migration and Dispersal Pathways in Vivid Three-Dimensional Detail. Cancer Research, 2011; DOI: 10.1158/0008-5472.CAN-11-1553

Cite This Page:

Case Western Reserve University. "Uncovering the spread of deadly cancer: New imaging device enables scientists to see tumor cells traveling in the brain." ScienceDaily. ScienceDaily, 26 August 2011. <www.sciencedaily.com/releases/2011/08/110826111227.htm>.
Case Western Reserve University. (2011, August 26). Uncovering the spread of deadly cancer: New imaging device enables scientists to see tumor cells traveling in the brain. ScienceDaily. Retrieved November 25, 2014 from www.sciencedaily.com/releases/2011/08/110826111227.htm
Case Western Reserve University. "Uncovering the spread of deadly cancer: New imaging device enables scientists to see tumor cells traveling in the brain." ScienceDaily. www.sciencedaily.com/releases/2011/08/110826111227.htm (accessed November 25, 2014).

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