Featured Research

from universities, journals, and other organizations

'TF beacons' may light path to new cancer tests and drugs

Date:
September 7, 2011
Source:
American Chemical Society
Summary:
Scientists are reporting development of a long-sought new way to detect the activity of proteins that bind to the DNA in genes, often controlling the activity of genes in ways that make cells do everything from growing normally to becoming cancerous.

Scientists are reporting development of a long-sought new way to detect the activity of proteins that bind to the DNA in genes, often controlling the activity of genes in ways that make cells do everything from growing normally to becoming cancerous.

Their report appears in the Journal of the American Chemical Society.

Kevin Plaxco, Francesco Ricci and colleagues note that more than 10 percent of the 25,000-30,000 genes in the human body contain instructions for manufacturing these so-called DNA-binding proteins. Most of these proteins are master regulators called transcription factors (TFs). They start or stop the first step in the process in which gene's instructions are put into action. TFs bind to DNA and turn genes on or off. Understanding and measuring the activity of TFs is important because they are involved in health and disease, with many linked to cancers, for instance. With existing ways of detecting the activity of TFs being slow and cumbersome, the scientists set out to overcome that barrier.

The scientists describe development and successful tests of fluorescent sensors that they term "transcription factor beacons." The beacons signal the activity and concentration of TFs directly in biological samples by switching from a dark state to a fluorescent state upon binding to their specific TF. Using TF Beacons is simpler and works faster than current methods, and the scientists say TF beacons may have multiple uses in diagnosing cancer, searching for new cancer drugs and other areas.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Alexis Vallée-Bélisle, Andrew J. Bonham, Norbert O. Reich, Francesco Ricci, Kevin W. Plaxco. Transcription Factor Beacons for the Quantitative Detection of DNA Binding Activity. Journal of the American Chemical Society, 2011; 133 (35): 13836 DOI: 10.1021/ja204775k

Cite This Page:

American Chemical Society. "'TF beacons' may light path to new cancer tests and drugs." ScienceDaily. ScienceDaily, 7 September 2011. <www.sciencedaily.com/releases/2011/09/110907104655.htm>.
American Chemical Society. (2011, September 7). 'TF beacons' may light path to new cancer tests and drugs. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2011/09/110907104655.htm
American Chemical Society. "'TF beacons' may light path to new cancer tests and drugs." ScienceDaily. www.sciencedaily.com/releases/2011/09/110907104655.htm (accessed October 21, 2014).

Share This



More Plants & Animals News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Cadaver Dog' Sniffs out Human Remains

'Cadaver Dog' Sniffs out Human Remains

AP (Oct. 21, 2014) Where's a body buried? Buster's nose can often tell you. He's a cadaver dog, specially trained to find human remains and increasingly being used by law enforcement and accepted in courts. These dogs are helping solve even decades-old mysteries. (Oct. 21) Video provided by AP
Powered by NewsLook.com
White Lion Cubs Born in Belgrade Zoo

White Lion Cubs Born in Belgrade Zoo

AFP (Oct. 20, 2014) Two white lion cubs, an extremely rare subspecies of the African lion, were recently born at Belgrade Zoo. They are being bottle fed by zoo keepers after they were rejected by their mother after birth. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com
Traditional Farming Methods Gaining Ground in Mali

Traditional Farming Methods Gaining Ground in Mali

AFP (Oct. 20, 2014) He is leading a one man agricultural revolution in Mali - Oumar Diatabe uses traditional farming methods to get the most out of his land and is teaching others across the country how to do the same. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Goliath Spider Will Give You Nightmares

Goliath Spider Will Give You Nightmares

Buzz60 (Oct. 20, 2014) An entomologist stumbled upon a South American Goliath Birdeater. With a name like that, you know it's a terrifying creepy crawler. Sean Dowling (@SeanDowlingTV) has the details. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

More Coverage


Nanosensors Made from DNA May Light Path to New Cancer Tests and Drugs

Sep. 7, 2011 Sensors made from custom DNA molecules could be used to personalize cancer treatments and monitor the quality of stem cells, according to new ... read more

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins