Featured Research

from universities, journals, and other organizations

Young women with early breast cancer have similar survival with breast conservation, mastectomy

Date:
September 7, 2011
Source:
University of Maryland Medical Center
Summary:
Young women with early-stage breast cancer have similar survival rates with a lumpectomy and radiation treatment, known as breast-conservation therapy, as with mastectomy, a new study has found.

Young women with early-stage breast cancer have similar survival rates with a lumpectomy and radiation treatment, known as breast-conservation therapy, as with mastectomy, a new study conducted at the University of Maryland has found. The results of the analysis of nearly 15,000 patients listed in a nationwide cancer registry will be presented at the 2011 Breast Cancer Symposium to be held Sept. 8-11 in San Francisco.

Steven J. Feigenberg, M.D., a radiation oncologist at the University of Maryland Marlene and Stewart Greenebaum Cancer Center and an associate professor of radiation oncology at the University of Maryland School of Medicine, says that mastectomies among young women have been on the rise, in part because of concerns regarding recurrence of their cancer.

"We believe these findings are very significant for young women with early-stage breast cancer who might choose to have a mastectomy in the hope of improving their outcome. This study confirms that breast-conservation therapy is a safe, effective treatment option and will not have a detrimental effect on survival," Dr. Feigenberg, the study's senior author, says.

He says this is the largest study to date to compare survival in young women with early-stage breast cancer who had breast-conservation therapy vs. mastectomy. Women under 40 can have more aggressive tumors and are often at higher risk for having their cancer recur. Previous studies have suggested that young women have higher local recurrences of their cancer with breast-conservation therapy, but these studies did not demonstrate an effect on survival, Dr. Feigenberg says.

Usama Mahmood, M.D., the lead author, says, "We looked at data from nearly 15,000 women in our retrospective analysis and saw no difference in survival between those who had breast-conservation therapy and those who had a mastectomy." Dr. Mahmood, a resident in the Department of Radiation Oncology at the University of Maryland who is now at the University of Texas M.D. Anderson Cancer Center, will present the data at the Breast Cancer Symposium.

E. Albert Reece, M.D., Ph.D., M.B.A., vice president of medical affairs at the University of Maryland and dean of the University of Maryland School of Medicine, says, "This large analysis breaks new ground in advancing what we know about how to treat young women with early-stage breast cancer. It will most certainly help young women and their doctors to better understand the most appropriate treatment options and make decisions based on what's best for each patient."

Researchers analyzed data from the SEER (Surveillance, Epidemiology and End Results) registry, which is maintained by the National Cancer Institute. They identified 14,764 women, age 20 to 39, who were diagnosed with early-stage breast cancer between 1990 and 2007. Forty-five percent of the women had breast-conservation surgery, and 55 percent had a mastectomy. Patients who received breast-conservation therapy were older and had smaller, lower-grade tumors and less lymph-node involvement. The median follow-up was nearly six years, although some patients were followed for 10 years, 15 years and beyond. All of the breast cancers were early-stage. Sixty-four percent of the patients were white.

To confirm the results of the study, the researchers did a "matched pair analysis, using a smaller group of 4,644 patients who had undergone breast-conservation therapy and mastectomy. Patients were matched for such factors as year of their diagnosis, age, grade, tumor size, number of positive lymph nodes, the number of nodes removed and their particular type of breast cancer, and still there was no difference in overall survival or survival specific to breast cancer. Similarly, a separate analysis was performed on the youngest group of patients, under age 33, again seeing no difference in outcomes.

The overall survival for those who had breast conservation therapy was 92.5 percent after five years, 83.5 percent after 10 years, and 77 percent after 15 years. That compares with 91.9 percent, 83.6 percent and 79.1 percent, respectively, for those who had mastectomies. In addition, the breast cancer-specific survival rates were similar between the two groups.

The study's authors include members of the multidisciplinary breast cancer team at the University of Maryland Greenebaum Cancer Center. In addition to Dr. Feigenberg, co-authors include Katherine Tkaczuk, M.D., a medical oncologist who heads the Breast Evaluation and Treatment Program; Susan Kesmodel, M.D., a surgical oncologist; and two medical oncologists, Saranya Chumsri, M.D., and Ting Bao, M.D.


Story Source:

The above story is based on materials provided by University of Maryland Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University of Maryland Medical Center. "Young women with early breast cancer have similar survival with breast conservation, mastectomy." ScienceDaily. ScienceDaily, 7 September 2011. <www.sciencedaily.com/releases/2011/09/110907132206.htm>.
University of Maryland Medical Center. (2011, September 7). Young women with early breast cancer have similar survival with breast conservation, mastectomy. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2011/09/110907132206.htm
University of Maryland Medical Center. "Young women with early breast cancer have similar survival with breast conservation, mastectomy." ScienceDaily. www.sciencedaily.com/releases/2011/09/110907132206.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins