Featured Research

from universities, journals, and other organizations

Computer-aided design used for breast tissue reconstruction

Date:
September 8, 2011
Source:
Institute of Physics
Summary:
A technology usually reserved for designing buildings, bridges and aircraft has now been used to aid breast tissue reconstruction in cancer patients.

A technology usually reserved for designing buildings, bridges and aircraft has now been used to aid breast tissue reconstruction in cancer patients.

In a study published Sept. 8 in IOP Publishing's journal Biofabrication, researchers used computer-aided design (CAD) to create an extremely accurate mould of a breast that was used as a visual aid to surgeons in tissue reconstruction operations.

Furthermore, CAD was used to design and produce patient-specific physical scaffolds that could potentially be used in conjunction with one of the most promising areas of medicine -- tissue engineering.

In theory, patients' own cells could be harnessed and grown onto the highly specific scaffold and then transferred to the affected area, avoiding the need to transfer tissue from other parts of the body which can cause large scars, result in considerable blood loss and require five to ten hours of anaesthesia.

Study co-author, Professor Dietmar Hutmacher, said, "We would take a laser scan of the healthy breast and use the CAD modeling process to design a patient-specific scaffold in silico. We would then produce a scaffold of very high porosity and load it with the patient's own cells in combination with a hydrogel. The construct would then be implanted."

CAD -- the use of computer technology in the process of design -- holds several advantages over traditional pen and paper approaches including the ability to work to full scale, examine the design from all angles and maintain absolute accuracy.

After informed consent, 3D laser scanning was performed on three female patients who suffered from breast cancer. The images were then fed into a piece of CAD-software which produced a single image representing the patient's breast and surrounding thorax region.

This image was then "printed" to form a 3D mould which was used as an operative aid for surgeons who performed autologous tissue reconstructions -- the transferring of tissue from another part of the patient's body -- on each of the patients.

After each of the operations, the surgeons observed a more perfect shape with a higher degree of symmetry between the breasts whilst, more importantly, the patients reported a higher satisfaction of the surgery outcomes than the control group, again with respect to shape and symmetry of their breasts.

The long-term aim of the study, however, was on the development of a material that could be used in tissue engineering and it showed that CAD could be an effective way of achieving this.

A function was created using the CAD software that enabled the creation of a mould for any scanned tissue with the ability to independently tailor the porosity and pore size -- a property that is essential to the seeding and diffusing of cells throughout the structure and something that limits modern technologies.

Professor Hutmacher continued, "The development of a clinically translatable method of engineering adipose tissue for soft tissue reconstruction requires investigation of several components.

"There must be coordination between all key aspects of the tissue engineering process, including the selection of cell source, scaffold material, cellular environment, and means of device delivery in order for the engineering of any tissue to be successful."

An Institute of Physics spokesperson said, "This advance offers hope to women who have undergone mastectomies. It's enlightening to see how a technique, first designed for the construction of buildings, bridges and aircraft, is now being used in medicine."


Story Source:

The above story is based on materials provided by Institute of Physics. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ferry Melchels, Paul Severin Wiggenhauser, David Warne, Mark Barry, Fook Rhu Ong, Woon Shin Chong, Dietmar Werner Hutmacher, Jan-Thorsten Schantz. CAD/CAM-assisted breast reconstruction. Biofabrication, 2011; 3: 034114 DOI: 10.1088/1758-5082/3/3/034114

Cite This Page:

Institute of Physics. "Computer-aided design used for breast tissue reconstruction." ScienceDaily. ScienceDaily, 8 September 2011. <www.sciencedaily.com/releases/2011/09/110907192318.htm>.
Institute of Physics. (2011, September 8). Computer-aided design used for breast tissue reconstruction. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2011/09/110907192318.htm
Institute of Physics. "Computer-aided design used for breast tissue reconstruction." ScienceDaily. www.sciencedaily.com/releases/2011/09/110907192318.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins