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Terahertz radiation's impact on cellular function and gene expression

Date:
September 13, 2011
Source:
Optical Society of America
Summary:
Relatively little is known about the effect of terahertz radiation on biological systems. A team of researchers have now evaluated the cellular response of mouse stem cells exposed to THz radiation. They reported that temperature increases were minimal, and that heat shock protein expression was unaffected, while the expression of certain other genes showed clear effects of the THz irradiation.

Terahertz (THz) technologies show promise for myriad medical, military, security, and research applications ranging from the detection of cancer to airport security systems to shipment inspection to spectroscopy. Relatively little is known, however, about the effect of THz radiation on biological systems. So a team of researchers, led by Los Alamos National Laboratory, evaluated the cellular response of mouse stem cells exposed to THz radiation.

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They applied low-power radiation both from a pulsed broadband (centered at 10 THz) source and from a continuous wave (CW) laser (2.52 THz) source, and applied both modeling and empirical characterization and monitoring techniques to minimize the impact of radiation-induced increases in temperature.

The researchers determined that temperature increases were minimal, and that heat shock protein expression was unaffected, while the expression of certain other genes showed clear effects of the THz irradiation. As the researchers describe in the September issue of the Optical Society's (OSA) open-access journal Biomedical Optics Express, mouse mesenchymal stem cells exposed to THz radiation exhibit specific changes in cellular function closely related to the gene expression. They believe further investigations involving a large number of genes and variation in THz radiation characteristics and exposure duration are needed to generalize their findings. They also say that more direct experimental investigations of THz radiation's ability to induce specific openings of the DNA double strand are needed to fully determine how THz radiation may work through DNA dynamics to influence cellular function.

The team, led by Los Alamos National Lab, worked in collaboration with the Center for Integrated Nanotechnologies, a U.S. Department of Energy, Office of Basic Energy Sciences user facility at Los Alamos and Sandia National Laboratories, and with Harvard Medical School, and Beth Israel Deaconess Medical Center.


Story Source:

The above story is based on materials provided by Optical Society of America. Note: Materials may be edited for content and length.


Journal Reference:

  1. Boian S. Alexandrov, Kim . Rasmussen, Alan R. Bishop, Anny Usheva, Ludmil B. Alexandrov, Shou Chong, Yossi Dagon, Layla G. Booshehri, Charles H. Mielke, M. Lisa Phipps, Jennifer S. Martinez, Hou-Tong Chen, George Rodriguez. Non-thermal effects of terahertz radiation on gene expression in mouse stem cells. Biomedical Optics Express, 2011; 2 (9): 2679 DOI: 10.1364/BOE.2.002679

Cite This Page:

Optical Society of America. "Terahertz radiation's impact on cellular function and gene expression." ScienceDaily. ScienceDaily, 13 September 2011. <www.sciencedaily.com/releases/2011/09/110913103217.htm>.
Optical Society of America. (2011, September 13). Terahertz radiation's impact on cellular function and gene expression. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2011/09/110913103217.htm
Optical Society of America. "Terahertz radiation's impact on cellular function and gene expression." ScienceDaily. www.sciencedaily.com/releases/2011/09/110913103217.htm (accessed December 19, 2014).

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