Featured Research

from universities, journals, and other organizations

Tumor environment keeps tumor-fighting T cells away

Date:
September 19, 2011
Source:
Rockefeller University Press
Summary:
Tumors have an arsenal of tricks to help them sidestep the immune system. A study reveals a new trick -- the ability to keep tumor-fighting T cells out by disabling a T cell-attracting protein within the tumor core.

Tumors have an arsenal of tricks to help them sidestep the immune system. A study published on September 19 in the Journal of Experimental Medicine reveals a new trick -- the ability to keep tumor-fighting T cells out by disabling a T cell-attracting protein within the tumor core.

Related Articles


The immune system faces many challenges in its attempt to fight off cancer. The tumor itself can promote the generation of naturally suppressive immune cells that keep their tumor-fighting brethren in check. Tumors can also create a hostile environment that hampers T cell function. The hostile environment is caused in part by the production of harmful reactive nitrogen species (RNS) inside the tumor.

RNS trigger the addition of small chemical modifications to proteins in their immediate vicinity. According to the new study, one of these RNS targets is CCL2, a small protein that attracts protective T cells to the tumor. Once modified by RNS, however, CCL2 is invisible to tumor-fighting T cells, which thus remain helplessly outside the tumor margins. By generating a drug that blocks RNS-induced chemical reactions or by injecting unmodified CCL2 into the tumor, the scientists restored the T cells' ability to invade.

If these findings hold up in humans, such RNS-blocking drugs might be combined with current therapies to help eradicate tumors more effectively.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Molon, B., et al. . Journal of Experimental Medicine, 2011 DOI: 10.1084/jem.20101956

Cite This Page:

Rockefeller University Press. "Tumor environment keeps tumor-fighting T cells away." ScienceDaily. ScienceDaily, 19 September 2011. <www.sciencedaily.com/releases/2011/09/110919121808.htm>.
Rockefeller University Press. (2011, September 19). Tumor environment keeps tumor-fighting T cells away. ScienceDaily. Retrieved November 1, 2014 from www.sciencedaily.com/releases/2011/09/110919121808.htm
Rockefeller University Press. "Tumor environment keeps tumor-fighting T cells away." ScienceDaily. www.sciencedaily.com/releases/2011/09/110919121808.htm (accessed November 1, 2014).

Share This



More Health & Medicine News

Saturday, November 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Melafind: Spotting Melanoma Without a Biopsy

Melafind: Spotting Melanoma Without a Biopsy

Ivanhoe (Oct. 31, 2014) The MelaFind device is a pain-free way to check suspicious moles for melanoma, without the need for a biopsy. Video provided by Ivanhoe
Powered by NewsLook.com
Battling Multiple Myeloma

Battling Multiple Myeloma

Ivanhoe (Oct. 31, 2014) The answer isn’t always found in new drugs – repurposing an ‘old’ drug that could mean better multiple myeloma treatment, and hope. Video provided by Ivanhoe
Powered by NewsLook.com
Chronic Inflammation and Prostate Cancer

Chronic Inflammation and Prostate Cancer

Ivanhoe (Oct. 31, 2014) New information that is linking chronic inflammation in the prostate and prostate cancer, which may help doctors and patients prevent cancer in the future. Video provided by Ivanhoe
Powered by NewsLook.com
Sickle Cell: Stopping Kids’ Silent Strokes

Sickle Cell: Stopping Kids’ Silent Strokes

Ivanhoe (Oct. 31, 2014) Blood transfusions are proving crucial to young sickle cell patients by helping prevent strokes, even when there is no outward sign of brain injury. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins