Featured Research

from universities, journals, and other organizations

Genetic differences may cause higher rates of prostate cancer in African-American men

Date:
September 20, 2011
Source:
American Association for Cancer Research
Summary:
Genetic differences in prostate cells seem to be a root cause of the prostate cancer disparities between African-American men and white men, according to new findings.

Genetic differences in prostate cells seem to be a root cause of the prostate cancer disparities between African-American men and white men, according to findings presented at the Fourth AACR Conference on The Science of Cancer Health Disparities, held here Sept. 18-21, 2011.

Related Articles


Prostate cancer is the second most common cancer among U.S. men, with occurrences and mortality rates higher in African-American men compared to white men.

"There are a lot of socioeconomic and environmental factors that create differences in levels of prostate cancer in these two groups," said Bi-Dar Wang, Ph.D., assistant research professor of pharmacology and physiology at the George Washington University. "We've found that genetic elements play a role in these disparities as well."

Wang and colleagues analyzed normal and cancerous prostate tissue samples from African-American and white men who underwent prostate biopsies. They looked at two key genetic pieces: messenger RNA (mRNA), which carry codes from DNA that is then used to make proteins; and microRNA, shorter RNA strands that regulate that process by binding to mRNA and interrupt the gene expression or protein translation.

The results showed enough differences between African-American and white men to determine that each race has "population specific" mRNA and microRNA.

Specifically, they found nearly 400 mRNAs were differentially expressed between the cancerous prostate tissues of African-American and white men. These differences are crucial because mRNA and microRNA affect the biological pathways by which prostate cancer tumor formation is either promoted or stopped, according to Wang.

Wang believes these results are important because instead of focusing on socioeconomic and environmental factors, the researchers focused on biological differences, which could lead to more specialized treatment options in the future.

"It is still too early to conclude any novel treatment strategy based on our results. However, the genomic analyses of prostate cancers have revealed that differential mRNA and microRNA expression and the associated gene network rewriting may be critical in prostate cancer health disparities," said Wang. "These findings will advance our knowledge on the molecular mechanisms underlying prostate cancer disparities and may help with the development of novel strategies for prostate cancer detection and personalized treatment for African-American men."


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Genetic differences may cause higher rates of prostate cancer in African-American men." ScienceDaily. ScienceDaily, 20 September 2011. <www.sciencedaily.com/releases/2011/09/110920100051.htm>.
American Association for Cancer Research. (2011, September 20). Genetic differences may cause higher rates of prostate cancer in African-American men. ScienceDaily. Retrieved February 28, 2015 from www.sciencedaily.com/releases/2011/09/110920100051.htm
American Association for Cancer Research. "Genetic differences may cause higher rates of prostate cancer in African-American men." ScienceDaily. www.sciencedaily.com/releases/2011/09/110920100051.htm (accessed February 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, February 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Reuters - Innovations Video Online (Feb. 27, 2015) A dongle that plugs into a Smartphone mimics a lab-based blood test for HIV and syphilis and can detect the diseases in 15 minutes, say researchers. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Doctor Says Head Transplants Possible Within Two Years

Doctor Says Head Transplants Possible Within Two Years

Buzz60 (Feb. 27, 2015) An Italian doctor is saying he could stick someone&apos;s head onto someone else&apos;s body. Patrick Jones (@Patrick_E_Jones) reports. Video provided by Buzz60
Powered by NewsLook.com
How Your Dentist Could Help Screen You For Diabetes

How Your Dentist Could Help Screen You For Diabetes

Newsy (Feb. 27, 2015) A new study from researchers at New York University suggests dentists could soon use blood samples taken from patients&apos; mouths to test for diabetes. Video provided by Newsy
Powered by NewsLook.com
The Best Tips to Makeover Your Health

The Best Tips to Makeover Your Health

Buzz60 (Feb. 27, 2015) If you&apos;re looking to boost your health this season, there are a few quick and easy steps to prompt you for success. Krystin Goodwin (@Krystingoodwin) has the best tips to give your health a makeover this spring! Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins