Featured Research

from universities, journals, and other organizations

Researchers explain hormonal role in glucose and fat metabolism

Date:
September 29, 2011
Source:
University of Houston
Summary:
Hormone researchers have their sights set on providing long-term treatment options for diabetes, obesity and cardiovascular diseases by better understanding estradiol, the most potent naturally occurring estrogen. They now believe that this estrogen hormone is a prominent regulator of several body functions in both females and males.

Hormone researchers at the University of Houston (UH) have their sights set on providing long-term treatment options for diabetes, obesity and cardiovascular diseases by better understanding estradiol, the most potent naturally occurring estrogen.

They now believe that this estrogen hormone is a prominent regulator of several body functions in both females and males. While estradiol is more commonly associated with processes and diseases specific to women, the team determined that the hormone actually functions as a unisex hormone with multiple actions. Research has indicated that when there is an excessive or insufficient amount of estradiol present, the metabolic network becomes imbalanced, which can result in metabolic diseases.

"Female hormones have always been associated with the menstrual cycle, pregnancy, breast-feeding and some diseases, such as osteoporosis and breast cancer, typically associated with women," said Dr. Rodrigo Barros, a research assistant professor with the UH Center for Nuclear Receptors and Cell Signaling (CNRCS). "Our group, however, has discovered that one of these hormones, estradiol, has much wider actions than previously thought. It is no longer considered exclusively a 'female sex hormone,' but a 'unisex hormone' with multiple actions across several organ systems."

Working with CNRCS director and professor Dr. Jan-Εke Gustafsson, Barros says that part of their research is dedicated to understanding how estradiol regulates feeding and food metabolism, explaining that this hormone is involved with several metabolic diseases, including eating disorders, obesity and diabetes.

"We believe that all the systems in the body involved with food consumption and metabolism, which include the brain, liver, pancreas, heart, muscles and fat, are connected by estradiol, resulting in a 'metabolic network' regulated by the hormone," Barros said. "Our evidence shows that when too much or too little estradiol is available, this delicate network loses its balance and metabolic diseases set in."

This research has important implications for the average consumer, as well as for physicians. While hormones like estradiol are important for the adequate maintenance of body functioning, they may pose serious risks to a person's health if misused as supplements. This comes into play when people use alternative forms of hormones, such as natural plant derivatives, that may be harmful if used inappropriately.

For specialists dealing with hormonal treatments, this research underscores that they should be aware that several organs and body functions are affected when estradiol is prescribed and may cause or worsen metabolic diseases. Due to the number of organs and functions affected by fluctuating levels of estradiol, its use as a hormonal treatment for patients with delayed puberty, menopausal symptoms, osteoporosis and prostate cancer is a source of debate within the medical and research communities. Exploring the impact of such treatments as reported by Barros and Gustafsson is helpful for keeping these professionals abreast of new research and guidelines.

Funded by the Robert A. Welch Foundation, the Emerging Technology Fund of Texas and the Cancer Prevention and Research Institute of Texas, the CNRCS team works in collaboration with Sweden's Karolinska Institutet.


Story Source:

The above story is based on materials provided by University of Houston. Note: Materials may be edited for content and length.


Journal Reference:

  1. Rodrigo P.A. Barros, Jan-Εke Gustafsson. Estrogen Receptors and the Metabolic Network. Cell Metabolism, 2011; 14 (3): 289 DOI: 10.1016/j.cmet.2011.08.005

Cite This Page:

University of Houston. "Researchers explain hormonal role in glucose and fat metabolism." ScienceDaily. ScienceDaily, 29 September 2011. <www.sciencedaily.com/releases/2011/09/110929122936.htm>.
University of Houston. (2011, September 29). Researchers explain hormonal role in glucose and fat metabolism. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2011/09/110929122936.htm
University of Houston. "Researchers explain hormonal role in glucose and fat metabolism." ScienceDaily. www.sciencedaily.com/releases/2011/09/110929122936.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) — Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) — At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) — Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins