Featured Research

from universities, journals, and other organizations

Fox Chase Gleason scores better predict prostate cancer's recurrence after radiation, study finds

Date:
October 5, 2011
Source:
Fox Chase Cancer Center
Summary:
In a new study, researchers have found that Gleason scores determined by pathologists at Fox Chase Cancer Center more accurately predict the risk of recurrence than Gleason scores from referring institutions.

In a new study led by Fox Chase Cancer Center radiation oncologist Natasha Townsend, M.D., researchers have found that Gleason scores determined by pathologists at Fox Chase Cancer Center more accurately predict the risk of recurrence than Gleason scores from referring institutions.

Related Articles


She presented the new research at the 53rd Annual Meeting of the American Society for Radiation Oncology on Oct. 3.

When a man is diagnosed with prostate cancer, his tumor is assigned a Gleason score -- a number between 2 and 10 indicating the aggressiveness of the cancer and likelihood that the cancer will spread to other parts of his body. In general, Gleason scores 2 to 6 are considered low, 7 is intermediate, and 8 to 10 are high. A patients Gleason score is used to make important treatment decisions.

Townsend and her team looked at the records of 1,649 men who had undergone radiation therapy at Fox Chase between 1994 and 2007. Fox Chase pathologists reviewed the cases of every patient referred to the Center from another institution and determined the Gleason score, so Townsend compared those scores to scores from pathologists at the referring institutions (e.g. urologists, private pathologists' offices, and other centers that specialize in prostate cancer treatment).

A minor increase or decrease in Gleason score can significantly alter a patient's treatment, says Townsend. "We learned that twenty percent, or one in five men, with a Gleason score 7 by the referring institution were determined to have a Gleason score 2 to 6 at Fox Chase," Townsend added. "This is important because not only is the prognosis much better but, it changes what treatment might be recommended. For example, patients with Gleason 6 disease are more likely to be offered brachytherapy (i.e. prostate radioactive seeding) and uncommonly treated with androgen deprivation therapy, which strongly impacts quality of life."

Even greater benefits were seen in patients determined to have Gleason score 8 to10 disease by the referring institution. "An alarming 58% of patients with Gleason score 8 to 10 disease in our study were unconfirmed. These patients were found to have lower Gleason scores and similarly better prognosis," says Townsend. Patients with Gleason score 8 to 10 are universally characterized as having "high-risk" disease and a common practice standard is treatment with combination external beam radiotherapy and hormone therapy. When the Gleason score is lower, physicians are more confident omitting hormone therapy and avoiding the side effects that go along with that treatment.

Pathologists who specialize in prostate cancer likely explain the difference between the Gleason scores. "Most cases were examined by an oncologic pathologist with a special experience in urologic pathology," says Tahseen Al-Seleem, M.D., Fox Chase pathologist and co-author on the study. "Cases with discrepancy in diagnosis or grading with the outside institutions were examined by a panel of at least two oncologic pathologists until a consensus diagnosis was reached."

Changing the Gleason score is meaningless however, unless the changes better predict how patients will do following treatment. "Historically, we know Gleason score 6 patients fare better than Gleason 7, who fare better than Gleason 8 to10. Our study shows that the Fox Chase Gleason scores better predicted this pattern than the referring institutions. This reassures us that the changes made by Fox Chase pathologists were more accurate, enabling our doctors to better advise patients about treatment options and outcomes," says Mark K. Buyyounouski, M.D., M.S., Fox Chase radiation oncologist and senior author on the study. "Quality treatment for prostate cancer begins with understanding how aggressive the cancer may be and how far along it may have progressed. This study is an example of how a second opinion about the biopsy results improves quality."

Co-investigators include Karen Ruth, Tahseen Al-Saleem, Eric Horwitz, Mark Sobczak, Robert Uzzo, Rosalia Viterbo, and Mark Buyyounouski from Fox Chase.


Story Source:

The above story is based on materials provided by Fox Chase Cancer Center. Note: Materials may be edited for content and length.


Cite This Page:

Fox Chase Cancer Center. "Fox Chase Gleason scores better predict prostate cancer's recurrence after radiation, study finds." ScienceDaily. ScienceDaily, 5 October 2011. <www.sciencedaily.com/releases/2011/10/111005111402.htm>.
Fox Chase Cancer Center. (2011, October 5). Fox Chase Gleason scores better predict prostate cancer's recurrence after radiation, study finds. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2011/10/111005111402.htm
Fox Chase Cancer Center. "Fox Chase Gleason scores better predict prostate cancer's recurrence after radiation, study finds." ScienceDaily. www.sciencedaily.com/releases/2011/10/111005111402.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins