Featured Research

from universities, journals, and other organizations

Residual damage after heart attack no longer inevitable

Date:
October 7, 2011
Source:
Medical University of Vienna
Summary:
A new treatment could revolutionize the treatment of patients after a heart attack. Medical researchers have developed a protein solution which can be used to reduce the scarring of tissue caused by inflammation after a heart attack.

Residual damage after heart attack no longer inevitable – MedUni Vienna unveils revolutionary approach to treatment
Credit: Image courtesy of Medical University of Vienna

A new treatment could revolutionize the treatment of patients after a heart attack. Hendrik Jan Ankersmit from the Medical University of Vienna has developed a protein solution which can be used to reduce the scarring of tissue caused by inflammation after a heart attack.

In 2009, 16,000 people were admitted to Austrian hospitals with an acute myocardial infarction, with 3,000 of them dying (source: Statistik Austria). Comparable figures from the European Union reveal 2.2 million deaths caused by ischaemic heart disease (source: WHO). Following the usually critical first phase of a heart attack, intensive rehabilitation is carried out and there is a risk of heart failure.

The results of the research carried out by Hendrik Jan Ankersmit, head of the CD Laboratory for Heart and Thorax Diagnosis and Regeneration at the MedUni Vienna, show that this need no longer be the case. Ankersmit has used white blood cells to create a protein solution (APOSEC™) that can be used as a drug during the acute therapy phase following a heart attack. In laboratory tests, the solution was administered as an intravenous infusion 40 minutes after an experimental infarction. As a result, there was virtually no scarring of the heart muscle.

APOSEC™ works by inhibiting the cardiac tissue's inflammatory response following a heart attack. Tests on human cardiac muscle cells -- with highly promising results -- have already been carried out in vitro. Researchers at the MedUni Vienna are hoping to start a series of clinical studies on humans in the near future.

Like blood in a blood bank -- available at all times APOSEC™ contains soluble proteins that are excreted by white blood cells. Harvesting white blood cells for use as 'bio-reactors' is as simple as taking blood. "With protein concentrates, there is little or no defence reaction from the body's immune system. APOSEC™ can therefore be obtained even from unrelated donors," says Ankersmit.

An even greater potential advantage over the conventional stem-cell-based treatment of myocardial infarctions is that the APOSEC™ protein solution can be produced in advance and stored for ready access, just like blood in a blood bank. In the event of an acute infarction, the patient can be treated immediately.


Story Source:

The above story is based on materials provided by Medical University of Vienna. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lichtenauer M, Mildner M, Hoetzenecker K, Zimmermann M, Podesser BK, Sipos W, Berιnyi E, Dworschak M, Tschachler E, Gyφngyφsi M, Ankersmit HJ. Secretome of apoptotic peripheral blood cells (APOSEC) confers cytoprotection to cardiomyocytes and inhibits tissue remodelling after acute myocardial infarction: a preclinical study. Basic Res Cardiol, 2011, Sep. 28

Cite This Page:

Medical University of Vienna. "Residual damage after heart attack no longer inevitable." ScienceDaily. ScienceDaily, 7 October 2011. <www.sciencedaily.com/releases/2011/10/111006084034.htm>.
Medical University of Vienna. (2011, October 7). Residual damage after heart attack no longer inevitable. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2011/10/111006084034.htm
Medical University of Vienna. "Residual damage after heart attack no longer inevitable." ScienceDaily. www.sciencedaily.com/releases/2011/10/111006084034.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) — Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) — The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) — Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:  

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile iPhone Android Web
      Follow Facebook Twitter Google+
      Subscribe RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins