Featured Research

from universities, journals, and other organizations

Gene signature predicts oral cancer recurrence

Date:
October 11, 2011
Source:
BioMed Central
Summary:
Oral squamous cell carcinoma (OSCC) is responsible for nearly a quarter of all head and neck cancers. It is one of the leading causes of cancer death -- largely due to the failure of current histological procedures in predicting the recurrence of the disease. New research shows that a four-gene signature may accurately predict which patients are at higher risk of OSCC recurrence.

Oral Squamous Cell Carcinoma (OSCC) is responsible for nearly a quarter of all head and neck cancers. It is one of the leading causes of cancer death -- largely due to the failure of current histological procedures in predicting the recurrence of the disease. New research published in BioMed Central's open access journal BMC Cancer shows that a four-gene signature may accurately predict which patients are at higher risk of OSCC recurrence.

Related Articles


A team of researchers, including Drs. Patricia Reis and Levi Waldron, and led by Dr Suzanne Kamel-Reid and Dr. Igor Jurisica, from the Ontario Cancer Institute at University Health Network (UHN) Toronto, Canada collected cancerous and noncancerous oral tissue samples from patients with OSCC from Toronto General Hospital at UHN.

They then used a meta-analysis of five published microarray studies along with their own microarray analysis to reliably identify 138 genes commonly over-expressed in both OSCC and normal margin tissues. Of these genes, a four-gene signature with the highest predictive risk of recurrence was selected. This signature contained cell invasion related genes MMP1, COL4A1, P4HA2 and THBS2.

The researchers explained: "Our data suggest that histologically normal surgical resection margins that over-express MMP1, COL4A1, THBS2 and P4HA2 are indicative of an increased risk of recurrence in OSCC. Patients at higher risk of recurrence could potentially benefit from closer disease monitoring and/or adjuvant post-operative radiation treatment, even in the absence of other clinical and histopathological indicators. Our findings may be applied to develop a molecular test, which could be clinically useful to help predict which patients are at a higher risk of local recurrence."


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Patricia P Reis, Levi Waldron, Bayardo Perez-Ordonez, Melania Pintilie, Natalie Naranjo Galloni, Yali Xuan, Nilva K Cervigne, Giles C Warner, Antti A Makitie, Colleen Simpson, David Goldstein, Dale Brown, Ralph Gilbert, Patrick Gullane, Jonathan Irish, Igor Jurisica and Suzanne Kamel-Reid. A gene signature in histologically normal surgical margins is predictive of oral carcinoma recurrence. BMC Cancer, 2011; (in press) [link]

Cite This Page:

BioMed Central. "Gene signature predicts oral cancer recurrence." ScienceDaily. ScienceDaily, 11 October 2011. <www.sciencedaily.com/releases/2011/10/111010212008.htm>.
BioMed Central. (2011, October 11). Gene signature predicts oral cancer recurrence. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2011/10/111010212008.htm
BioMed Central. "Gene signature predicts oral cancer recurrence." ScienceDaily. www.sciencedaily.com/releases/2011/10/111010212008.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins