Featured Research

from universities, journals, and other organizations

Little evidence found to support use of PET-CT in primary bowel cancer, study finds

Date:
October 14, 2011
Source:
NIHR
Summary:
New research has found little evidence to support the use of PET-CT add-on imaging device in the pre-operative staging of bowel cancer.

Research published in Health Technology Assessment has found little evidence to support the use of PET-CT add-on imaging device in the pre-operative staging of bowel cancer.

Worldwide, large bowel colorectal cancer accounts for more than one million cancers per year. In the UK, bowel cancer is the third commonest malignancy behind lung and breast cancer.

Several diagnostic tests are used to assess the extent of a cancer; ultrasound, magnetic resonance imaging (MRI), computerised tomography (CT) and contrast enhanced computerised tomography (CT) scanning of the chest abdomen and pelvis as well as a full blood count and biochemical profile. These can all inform the prognosis prior to surgical resection. The presence of disease distant to the site of planned surgery impacts upon type and timing of treatments. Together, this wide variation in presentations and extents of treatments underpin the rationale for accurate pre-operative staging.

The research is funded by the National Institute for Health Research Health Technology Assessment (NIHR HTA) programme and led by Professor David Weller of the University of Edinburgh. The researchers reviewed existing evidence on the diagnostic accuracy and therapeutic impact of an add on of CT in combination with Positron Emission Tomography -- Computed Tomography (FDG PET-CT) scanning. Integrated FDG PET-CT equipment is the latest imaging technology to be used for the pre-operative staging of colorectal cancer.

The team found limited evidence to support the use of FDG PET-CT in the pre-operative staging of primary, recurrent and spreading of colorectal cancer. Although FDG PET-CT was shown to change patient management the data was divergent and the quality of research studied was generally poor. Studies reported inconsistent findings about the effect FDG PET-CT had on surgical management. In addition, it was found that the published research evaluating FDG PET-CT for primary and recurrent bowel colorectal cancer did not reflect routine UK clinical practice at this time.

However, the research did show that FDG PET-CT as an add-on imaging device is cost-effective in the pre-operative staging of recurrent colon, recurrent rectal and metastatic disease, but it was not cost -effective for primary colon or primary rectal cancers.

Professor Weller commented: "There is uncertainty about the value of using FDG PET-CT in the treatment of bowel colorectal cancer. Importantly, practitioners who access this imaging technology need to routinely collect data to enable audits of patient outcomes, including detection rate and any changes in management resulting from its use."


Story Source:

The above story is based on materials provided by NIHR. Note: Materials may be edited for content and length.


Journal Reference:

  1. J Brush, K Boyd, F Chappell, F Crawford, M Dozier, E Fenwick, J Glanville, H McIntosh, A Renehan, D Weller, M Dunlop. The value of FDG positron emission tomography/ computerised tomography (PET/CT) in pre-operative staging of colorectal cancer: a systematic review and economic evaluation. Health Technology Assessment, 2011; 15 (35) DOI: 10.3310/hta15350

Cite This Page:

NIHR. "Little evidence found to support use of PET-CT in primary bowel cancer, study finds." ScienceDaily. ScienceDaily, 14 October 2011. <www.sciencedaily.com/releases/2011/10/111014080043.htm>.
NIHR. (2011, October 14). Little evidence found to support use of PET-CT in primary bowel cancer, study finds. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2011/10/111014080043.htm
NIHR. "Little evidence found to support use of PET-CT in primary bowel cancer, study finds." ScienceDaily. www.sciencedaily.com/releases/2011/10/111014080043.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins