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Patients with inflammatory bowel disease appear to be at increased risk for developing post-operative deep vein thrombosis and pulmonary embolism

Date:
October 17, 2011
Source:
JAMA and Archives Journals
Summary:
Patients with inflammatory bowel disease undergoing surgery may be more likely to develop deep vein thrombosis or pulmonary embolism following surgical procedures, according to a new study.

Patients with inflammatory bowel disease (IBD) undergoing surgery may be more likely to develop deep vein thrombosis (DVT; blood clot in a deep vein in the thigh or leg) or pulmonary embolism (PE; blood clot in blood vessels in the lungs) following surgical procedures, according to a study published Online First by Archives of Surgery, one of the JAMA/Archives journals.

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"An increased risk of DVT and PE in patients with IBD has been evident for the past 75 years," the authors write as background information for the article. "Most work in this area has not looked specifically at patients undergoing surgery. Patients with IBD frequently require surgical intervention, and an understanding of their risk of venous thromboembolism is therefore an important issue."

Andrea Merrill, M.D., from Massachusetts General Hospital, Boston, and Frederick Millham, M.D., from Newton-Wellesley Hospital, Boston, analyzed 2008 data from the 211 hospitals participating in the American College of Surgeons National Surgical Quality Improvement Program (NSQIP). Of the 268,703 patients, 2,249 patients had IBD (0.8 percent) and they were compared with 269,119 patients without IBD.

Among all the patients, there were 2,665 cases of DVT or PE (1.0 percent). "Occurrence of DVT or PE was more common in patients with IBD (2.5 percent) overall. Nonintestinal surgical cases had a higher rate of DVT or PE (5.0 percent)," the authors report. "Inflammatory bowel disease had no effect on risk of postoperative myocardial infarction (heart attack) or stroke."

"In conclusion, this study of patients enrolled in the NSQIP database demonstrates that patients with IBD who undergo surgery have a two-fold increased risk of DVT or PE. In patients with IBD who are having nonintestinal surgery, this risk may be even higher. These findings suggest that standard DVT and PE prophylaxis [prevention] should be reconsidered for this patient group."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Andrea Merrill; Frederick Millham. Increased Risk of Postoperative Deep Vein Thrombosis and Pulmonary Embolism in Patients With Inflammatory Bowel Disease: A Study of National Surgical Quality Improvement Program Patients. Archives of Surgery, 2011; DOI: 10.1001/archsurg.2011.297

Cite This Page:

JAMA and Archives Journals. "Patients with inflammatory bowel disease appear to be at increased risk for developing post-operative deep vein thrombosis and pulmonary embolism." ScienceDaily. ScienceDaily, 17 October 2011. <www.sciencedaily.com/releases/2011/10/111017170824.htm>.
JAMA and Archives Journals. (2011, October 17). Patients with inflammatory bowel disease appear to be at increased risk for developing post-operative deep vein thrombosis and pulmonary embolism. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2011/10/111017170824.htm
JAMA and Archives Journals. "Patients with inflammatory bowel disease appear to be at increased risk for developing post-operative deep vein thrombosis and pulmonary embolism." ScienceDaily. www.sciencedaily.com/releases/2011/10/111017170824.htm (accessed March 30, 2015).

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