Featured Research

from universities, journals, and other organizations

Blood test could identify smokers at higher risk for heart disease, UT Southwestern researchers find

Date:
October 26, 2011
Source:
UT Southwestern Medical Center
Summary:
A simple blood test could someday quantify a smoker's lung toxicity and danger of heart disease, researchers at UT Southwestern Medical Center have found.

A simple blood test could someday quantify a smoker's lung toxicity and danger of heart disease, researchers at UT Southwestern Medical Center have found.

Nearly one in five adults in the U.S. smoke, and smoking-related medical expenses and loss of productivity exceeds $167 billion annually, according to the Centers for Disease Control and Prevention. Levels of a lung protein found in the blood of smokers could indicate their risk of dangerous plaque buildup in blood vessels, said Dr. Anand Rohatgi, assistant professor of internal medicine at UT Southwestern and co-lead author of the study available in Arteriosclerosis, Thrombosis, and Vascular Biology, a publication of the American Heart Association.

"We now are close to having a blood test to help measure the smoking-related effects that contribute to atherosclerotic heart disease," Dr. Rohatgi said. "Smoking is one of the biggest contributors to the development of heart disease."

Smokers are at an increased risk of heart attack, stroke and dying from heart disease, but the risk varies among individuals. Until this study, there had been no simple blood test to measure the varied effects of smoking on heart disease.

Researchers determined the amount of circulating pulmonary surfactant B (SP-B), a protein found in damaged lung cells, in more than 3,200 Dallas Heart Study participants ages 30 to 65. The Dallas Heart Study was a groundbreaking investigation of cardiovascular disease that first involved more than 6,100 Dallas County residents who provided blood samples and underwent blood vessel scans with magnetic resonance imaging and computerized tomography.

The researchers found that smokers who had higher levels of SP-B also had more buildup of dangerous plaque in the aorta -- the largest artery in the body, with branches leading to the abdomen, pelvis and legs.

The test is still being evaluated and is not available for commercial use. The next step, said Dr. Rohatgi, is to investigate whether SP-B causes atherosclerosis or is simply a marker of the disease, and to determine whether decreasing levels of SP-B will improve heart disease outcomes.

Other UT Southwestern researchers involved in the study were co-lead author Dr. Ann Nguyen, resident in internal medicine; Dr. Christine Garcia, assistant professor in the Eugene McDermott Center for Human Growth and Development and in internal medicine; Colby Ayers, faculty associate in clinical sciences; Dr. Sandeep Das, assistant professor of internal medicine; Dr. Susan Lakoski, assistant professor of internal medicine; Dr. Jarett Berry, assistant professor of internal medicine; Dr. Amit Khera, associate professor of internal medicine; Dr. Darren McGuire, associate professor of internal medicine; and Dr. James de Lemos, professor of internal medicine.

The study was funded by the Donald W. Reynolds Foundation and the National Institutes of Health. Alere provided assay measurements.


Story Source:

The above story is based on materials provided by UT Southwestern Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. B. Nguyen, A. Rohatgi, C. K. Garcia, C. R. Ayers, S. R. Das, S. G. Lakoski, J. D. Berry, A. Khera, D. K. McGuire, J. A. de Lemos. Interactions Between Smoking, Pulmonary Surfactant Protein B, and Atherosclerosis in the General Population: The Dallas Heart Study. Arteriosclerosis, Thrombosis, and Vascular Biology, 2011; 31 (9): 2136 DOI: 10.1161/ATVBAHA.111.228692

Cite This Page:

UT Southwestern Medical Center. "Blood test could identify smokers at higher risk for heart disease, UT Southwestern researchers find." ScienceDaily. ScienceDaily, 26 October 2011. <www.sciencedaily.com/releases/2011/10/111025091644.htm>.
UT Southwestern Medical Center. (2011, October 26). Blood test could identify smokers at higher risk for heart disease, UT Southwestern researchers find. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2011/10/111025091644.htm
UT Southwestern Medical Center. "Blood test could identify smokers at higher risk for heart disease, UT Southwestern researchers find." ScienceDaily. www.sciencedaily.com/releases/2011/10/111025091644.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins