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Depression and chronic stress accelerates aging

Date:
November 10, 2011
Source:
Umeå University
Summary:
People with recurrent depressions or those exposed to chronic stress exhibits shorter telomeres in white blood cells.

People with recurrent depressions or those exposed to chronic stress exhibits shorter telomeres in white blood cells. This is shown by a research team at Umeå University in a coming issue of Biological Psychiatry.

The telomere is the outermost part of the chromosome. With increasing age, telomeres shorten, and studies have shown that oxidative stress and inflammation accelerates this shortening. On this basis it has been suggested that telomere length is a measure of biological aging, and telomere length has subsequently been linked to age-related diseases, unhealthy lifestyle, and longevity. The research team shows that shorter telomere length is associated with both recurrent depression and cortisol levels indicative of exposure to chronic stress.

The study includes 91 patients with recurrent depression and 451 healthy controls. Telomere length, measured in white blood cells, is shorter among the patients compared with the control group. The scientists also examined the participants' stress regulation using a so-called dexamethasone suppression test.

"The test revealed that cortisol levels indicative of chronic stress stress are associated with shorter telomeres in both depressed and healthy individuals," says Mikael Wikgren, a doctoral candidate in the research group. The fact that depressed patients as a group have shorter telomere lengths compared to healthy individuals can be largely explained by the fact that more depressed people than healthy people have disturbed cortisol regulation, which underscores that cortisol regulation and stress play a major role in depressive disorders.

The article is part of Mikael Wikgren's dissertation work. The research team, led by Professor Rolf Adolfsson, also includes Karl-Fredrik Norrback, Ph.D, (supervisor), doctoral candidate Martin Maripuu, and project coordinator Annelie Nordin. The study was carried out in collaboration with researchers from the Department of Medical Bioscience, Umeå University, as well as scientists at Stockholm University, Linköping University, and Antwerp University.


Story Source:

The above story is based on materials provided by Umeå University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mikael Wikgren, Martin Maripuu, Thomas Karlsson, Katarina Nordfjäll, Jan Bergdahl, Johan Hultdin, Jurgen Del-Favero, Göran Roos, Lars-Göran Nilsson, Rolf Adolfsson, Karl-Fredrik Norrback. Short Telomeres in Depression and the General Population Are Associated with a Hypocortisolemic State. Biological Psychiatry, 2011; DOI: 10.1016/j.biopsych.2011.09.015

Cite This Page:

Umeå University. "Depression and chronic stress accelerates aging." ScienceDaily. ScienceDaily, 10 November 2011. <www.sciencedaily.com/releases/2011/11/111109093729.htm>.
Umeå University. (2011, November 10). Depression and chronic stress accelerates aging. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2011/11/111109093729.htm
Umeå University. "Depression and chronic stress accelerates aging." ScienceDaily. www.sciencedaily.com/releases/2011/11/111109093729.htm (accessed April 24, 2014).

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