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The leading edge of stress: New genomic, optogenetic and epigenetic findings

Date:
November 16, 2011
Source:
Society for Neuroscience
Summary:
New research uses the latest genetic tools to explore how stress alters brain function, leading to anxiety, depression, and other stress-related mood disorders.
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Scientists are discovering promising approaches to treating pain, one of the most common and debilitating neurological complaints, according to research released November 15 at Neuroscience 2011, the annual meeting of the Society for Neuroscience and the world's largest source of emerging news about brain science and health. Studies show that "mirror box therapy" can help reduce arthritis-related pain, and that a new opioid-like drug may be able to relieve acute pain without the euphoric effects that can lead to dependency. Additional research also identifies the possible neurobiological source of common side effects of morphine.

Specifically, today's new findings show that:

  • Two of morphine's most common side effects, itch and headache, may be due to the drug's activation of immune cells in the membrane surrounding the brain and spinal cord (Julie Wieseler, PhD, abstract 178.12, see summary attached).
  • A visual feedback technique called mirror box therapy can help alleviate hand pain in patients with arthritis (Laura Case, abstract 72.03, see summary attached).
  • In an animal study, a novel drug relieves acute pain without the dangerous side effects associated with opioid painkillers such as morphine (Stephen Harrison, PhD, abstract 178.10, see summary attached).

Other recent findings discussed show:

  • A gene therapy treatment reduced pain in 10 people in a Phase I clinical trial that tested for treatment safety (David Fink, MD, see attached speaker's summary).
  • A naturally occurring protein that supports the survival and growth of neurons in the brain and spinal cord may be a potential therapeutic intervention to prevent chronic pain following spinal cord injuries, according to animal research (Ching-Yi Lin, PhD, see attached speaker's summary).

"Pain is one of the most intransigent and difficult symptoms to treat," said Allan I. Basbaum, PhD, FRS, of the University of California, San Francisco, press conference moderator and expert on the neurobiology of pain. "These studies and others are helping us better understand the complex neural pathways involved in pain and the long-term consequences of injury. With this, researchers will be better poised to develop approaches to alleviate pain and aid in recovery from injuries."


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The above story is based on materials provided by Society for Neuroscience. Note: Materials may be edited for content and length.


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Society for Neuroscience. "The leading edge of stress: New genomic, optogenetic and epigenetic findings." ScienceDaily. ScienceDaily, 16 November 2011. <www.sciencedaily.com/releases/2011/11/111115175809.htm>.
Society for Neuroscience. (2011, November 16). The leading edge of stress: New genomic, optogenetic and epigenetic findings. ScienceDaily. Retrieved May 24, 2015 from www.sciencedaily.com/releases/2011/11/111115175809.htm
Society for Neuroscience. "The leading edge of stress: New genomic, optogenetic and epigenetic findings." ScienceDaily. www.sciencedaily.com/releases/2011/11/111115175809.htm (accessed May 24, 2015).

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